Evidence map›Paper›PMID 41929052›Full record

ArticlebioRxiv : the preprint server for biology2026

Ca

J Zhou, C Dogan, L L Artico, K Rodrigues, S Hakam, T Kim, V Xu, K Lapenta, M Kang, D M Jorgens and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

J ZhouDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, Berkeley, CA 94720, USA.
C DoganDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, Berkeley, CA 94720, USA.
L L ArticoDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, Berkeley, CA 94720, USA.
K RodriguesDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, Berkeley, CA 94720, USA.
S HakamDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, Berkeley, CA 94720, USA.
T KimDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, Berkeley, CA 94720, USA.
V XuDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, Berkeley, CA 94720, USA.
K LapentaDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, Berkeley, CA 94720, USA.
M KangElectron Microscope Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA.
D M JorgensElectron Microscope Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA.
S B WidenmaierDepartment of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatchewan, Canada.ORCID 0000-0001-5684-2707
G ParlakgulDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-9365-7287
A P ArrudaDepartment of Metabolic Biology and Nutrition, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-6179-2687

Funding

UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
ICP-QQQS10OD030258 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI JORGENS, DANIELLE MARY · 2021 to 2021
$1.6M
The role of hepatic Endoplasmic Reticulum architecture in metabolic homeostasis and diseaseR01DK140367 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI Ana Paula Arruda · 2024 to 2026
$1.2M
Acquisition of Covaris E220 and Sciclone G3 systems for high throughput sequencinS10OD010786 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI COMAI, LUCA · 2012 to 2012
$311k
NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK140367NIH HHS S10 OD010786NIH HHS S10 OD030258
6 · The paper itself

Abstract

Brown adipose tissue (BAT) exhibits exceptional metabolic plasticity, rapidly increasing energy expenditure to sustain thermogenesis during cold exposure. This high metabolic activity imposes substantial demands on cellular systems, requiring robust adaptive mechanisms to maintain homeostasis and prevent cellular stress. Yet, the pathways that support and coordinate these adaptive responses in brown adipocytes remain incompletely understood. Here, we identify a cold-induced adaptive program in BAT characterized by the formation of endoplasmic reticulum-plasma membrane (ER-PM) contact sites and the activation of store-operated calcium entry (SOCE), which is essential for maintaining brown adipocyte health during thermogenic activation. Cold exposure enhances ER-PM contacts and upregulates the expression of STIM and Orai proteins, key mediators of SOCE. Loss of STIM in brown adipocytes disrupts intracellular Ca

Identifiers

PMID41929052
PMCPMC13041958

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.