Evidence map›Paper›PMID 41929083›Full record

ArticlebioRxiv : the preprint server for biology2026

A uniquely leptin sensitive hypothalamic neuron population limits hyperphagia and weight gain in diet-induced obesity.

Dylan M Belmont-Rausch, Benedicte Schultz Kapel, Abigail J Tomlinson, Chao Ding, Allison M Duensing, Bernd Coester, Cecilie Vad Mathiesen, Leonie Cabot, Jenny M Brown, Charlotte Høy Kruse and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Dylan M Belmont-RauschNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Benedicte Schultz KapelNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Abigail J TomlinsonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.
Chao DingResearch Group Synaptic Transmission in Energy Homeostasis, Max Planck Institute for Metabolism Research, 50931 Cologne, Germany.
Allison M DuensingDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.
Bernd CoesterNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Cecilie Vad MathiesenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Leonie CabotResearch Group Synaptic Transmission in Energy Homeostasis, Max Planck Institute for Metabolism Research, 50931 Cologne, Germany.
Jenny M BrownNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Charlotte Høy KruseNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Christoffer ClemmensenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Michael W SchwartzDiabetes and Obesity Center of Excellence, Department of Medicine, University of Washington at South Lake Union, Seattle, Washington.
Henning FenselauResearch Group Synaptic Transmission in Energy Homeostasis, Max Planck Institute for Metabolism Research, 50931 Cologne, Germany.
Martin G MyersDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.ORCID 0000-0001-9468-2046
Tune H PersNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-0207-4831

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
MOLECULAR DETERMINANTS OF LEPTIN RECEPTOR/JAK2 SIGNALINGR01DK056731 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYERS, MARTIN G · 1999 to 2025
$6.0M
Thermoregulatory circuits that regulate feedingR01DK124238 · NIDDK · UNIVERSITY OF WASHINGTON · PI GREGORY J MORTON, Tune Hannes Pers · 2020 to 2026
$3.9M
NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK056731NIDDK NIH HHS R01 DK124238
6 · The paper itself

Abstract

Despite widespread loss of leptin responsiveness in obesity, endogenous leptin continues to restrain feeding, yet the neural substrates that remain sensitive and mediate this effect are unknown. Combining spatial transcriptomics with single-nucleus RNA sequencing in mice with diet-induced obesity (DIO), we show that while most hypothalamic leptin receptor (

Identifiers

PMID41929083
PMCPMC13041805

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.