ArticlebioRxiv : the preprint server for biology2026
An unexpected specialization of the active zone scaffold RIM at high release synapses.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The active zone scaffold RIM is canonically viewed as an obligate, universal pillar of the neurotransmitter release machinery. However, whether RIM is strictly required across diverse synapse subtypes with distinct release probabilities has remained an important unresolved question. Here, we report a fundamental revision of this model: RIM is not a constitutive necessity for baseline transmission, but rather a specialized "gain factor" selectively deployed to empower high-release synapses. Utilizing botulinum neurotoxin-based silencing to isolate convergent inputs at the Drosophila neuromuscular junction, we demonstrate that while RIM is essential for high-fidelity transmission at phasic (MN-Is) synapses, it is largely dispensable at low-release tonic (MN-Ib) synapses. This input specificity extends into plasticity: RIM is required for acute presynaptic homeostatic potentiation (PHP) at phasic inputs but is dispensable for the chronic maintenance of PHP at tonic inputs. Mechanistically, super-resolution imaging reveals that RIM is positioned significantly closer to Ca
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