Evidence map›Paper›PMID 41929151›Full record

ArticlebioRxiv : the preprint server for biology2026

Post-Transcriptional Size-Dependent Expression of the Fission Yeast Cdc13 Cyclin.

Samirul Bashir, Xi-Ming Sun, Yixuan Zhao, Nuria G Martínez-Illescas, Isabella M Gallego Lopez, Lauren Guerrero Negrón, Makoto Ohiro, Daniel Keifenheim, Tatiana Karadimitriou, Mary Pickering and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Samirul BashirDepartment of Biochemistry and Molecular Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Xi-Ming SunMRC Laboratory of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK.
Yixuan ZhaoDepartment of Biochemistry and Molecular Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Nuria G Martínez-IllescasDepartment of Biochemistry and Molecular Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Isabella M Gallego LopezDepartment of Biochemistry and Molecular Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Lauren Guerrero NegrónDepartment of Biochemistry and Molecular Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Makoto OhiroDepartment of Biochemistry and Molecular Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Daniel KeifenheimDepartment of Biochemistry and Molecular Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Tatiana KaradimitriouDepartment of Biochemistry and Molecular Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Mary PickeringDepartment of Biochemistry and Molecular Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Samuel MargueratMRC Laboratory of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK.
Nicholas RhindDepartment of Biochemistry and Molecular Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.ORCID 0000-0003-1758-7736

Funding

Regulation of Key Cell Cycle EventsR35GM148359 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI NICHOLAS R RHIND · 2023 to 2026
$3.1M
The Mechanism of Cell Size Regulation - Administrative SupplementR01GM134300 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RHIND, NICHOLAS R · 2020 to 2023
$1.4M
NIGMS NIH HHS R01 GM134300NIGMS NIH HHS R35 GM148359
6 · The paper itself

Abstract

The major fission yeast cyclin, Cdc13, has been shown to increase in concentration in correlation with cell size, and has been proposed to thereby regulate cell size at division. However, the mechanism of its cell-size regulation has been unknown. Here, we show that Cdc13 is regulated post-transcriptionally. Its transcript is not expressed in a size-dependent manner, rather a size-dependent concentration of protein is expressed from a size-independent concentration of mRNA. Moreover, we show that the expression of Cdc13 is, in fact, size dependent, as opposed to simply size-correlated due to time-dependent expression. We identify a 20-amino-acid motif, which includes the APC D-box degron, as necessary and sufficient for size-dependent expression, which allowed us to construct a size-independent allele of

Identifiers

PMID41929151
PMCPMC13041783

What Socratic holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.