Evidence map›Paper›PMID 41929473›Full record

ArticleFrontiers in cardiovascular medicine2026

Fructose and salt induce sex- and ovary dependent cardiac hypertrophy in Dahl salt-sensitive rats.

M A Akhtar, S Ludvigsen, C Mancusi, G de Simone, A D Hafstad, E Gerdts, K Ytrehus

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Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

M A AkhtarDepartment of Medical Biology, UiT-The Arctic University of Norway, Tromsø, Norway.
S LudvigsenDepartment of Medical Biology, UiT-The Arctic University of Norway, Tromsø, Norway.
C MancusiDepartment of Advanced Biomedical Science, University of Naples Frederico II, Naples, Italy.
G de SimoneDepartment of Advanced Biomedical Science, University of Naples Frederico II, Naples, Italy.
A D HafstadDepartment of Medical Biology, UiT-The Arctic University of Norway, Tromsø, Norway.
E GerdtsDepartment of Clinical Science, University of Bergen, Bergen, Norway.
K YtrehusDepartment of Medical Biology, UiT-The Arctic University of Norway, Tromsø, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The consumption of sugar and salt plays a pivotal role in the development of metabolic disorders, hypertension, and subsequent cardiovascular morbidity. This study investigates the influence of sex and gonadal status on early signs of cardiac remodeling in hypertensive-prone Dahl salt-sensitive (DSS) rats by comparing male, female, and ovariectomized (OVX) female rats. DSS rats were provided with 10% fructose in their drinking water and subjected to either a high-salt diet (6% NaCl) or a standard-salt diet (0.3% NaCl) for 8 weeks. Mean arterial pressure, initially 115 ± 2 mmHg at baseline across all groups, increased to 127 ± 5 mmHg with the standard-salt diet and to 156 ± 7 mmHg with the high-salt diet (

Indexed as

cardiac remodelingdahl salt-sensitive ratsdietary factorsechocardiographyfructosegene expressionsalt-sensitive hypertensionsex hormones

Identifiers

PMID41929473
PMCPMC13039016

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.