Evidence map›Paper›PMID 41929483›Full record

ArticleFrontiers in immunology2026

Double negative T cells (CD4

Jung-Sun Cho, Supriya Kumar, Erica Silberstein, Xuefei Ma, Alexander Zhovmer, Alain Debrabant

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jung-Sun ChoLaboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.
Supriya KumarLaboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.
Erica SilbersteinLaboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.
Xuefei MaLaboratory of Immunobiochemistry, Division of Bacterial, Parasitic & Allergenic Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.
Alexander ZhovmerLaboratory of Immunobiochemistry, Division of Bacterial, Parasitic & Allergenic Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.
Alain DebrabantLaboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Chagas disease (CD), caused by the blood borne parasite Methods: C57BL/6 mice were infected with a transgenic strain of Results: We showed that DN T cells were the major lymphocyte population in this tissue by flow cytometry and fluorescence microscopy. The number of DN T cells increased significantly (~1.5 fold) during the acute phase and remained above control levels during the chronic infection. Two major subtypes were identified: (1) DN T cells with inflammatory phenotypes, which peaked in the acute phase and declined in the chronic phase but remained above control levels, and (2) DN T cells with regulatory phenotypes, which were elevated in both phases. Discussion: Our findings highlight the critical role of colonic DN T cells in an experimental

Indexed as

Chagas DiseaseColonT-Lymphocyte SubsetsTrypanosoma cruziAnimalsChronic DiseaseDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLChagas diseasecolondouble-negative (DN) T cellsinflammatory DN T cellsparasite persistenceregulatory DN T cellsTrypanosoma cruzi

Identifiers

PMID41929483
PMCPMC13038538

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.