ArticleJournal of anesthesia and translational medicine2024
Association between opioids use and risk of multiple cancers: A two-sample Mendelian randomization study.
Article in Journal of anesthesia and translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Effect of Transcranial Alternating Current Stimulation on Prevention of Postoperative Pain After Video-Assisted Thoracic Surgery: A Randomized Controlled Trial.Pain research & management · 2026Trial
- Potential drug targets for systemic lupus erythematosus identified through Mendelian randomization analysis.Medicine · 2025Article
- Postoperative Multimodal Analgesia Strategy for Enhanced Recovery After Surgery in Elderly Colorectal Cancer Patients.Pain and therapy · 2024Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Previous observational studies have investigated the possible link between opiate use and the risk of cancer. Nevertheless, there is still no solid evidence linking opioids to any particular type of cancer. Methods: In the present study, we performed a two-sample Mendelian randomization (MR) study to elucidate the potential causal effects of opioid use on cancers risk. To find appropriate instrumental single nucleotide polymorphisms (SNPs) linked to the exposure of interest, a stringent quality control procedure was first applied. We evaluated the association between opioids and cancers risk using the inverse-variance weighted (IVW) method,. Additionally, we conducted sensitivity analyses employing the simple mode, weighted mode, MR-Egger, weighted median and MR-PRESSO tests to complement our findings. Results: Based on the results of IVW analysis, our study indicated a positive causal relationship between opioids and lung cancer (OR=1.001, 95% CI: 1.000-1.003, Conclusions: This study sheds light on the potential association between opioid use and the risk of developing lung and kidney cancers. Nonetheless, it's worth noting that no statistically significant relationship between opioids use and various other types of cancer was identified.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.