ArticleFrontiers in neurology
The impact of intracranial artery stenosis on the prognosis of non-dialysis patients with chronic kidney disease.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the impact of intracranial artery stenosis (ICAS) on the prognosis of patients with non-dialysis chronic kidney disease (CKD). Methods: We retrospectively analyzed data from non-dialysis CKD patients who were hospitalized in the Department of Nephrology, Xuanwu Hospital, Capital Medical University, from January 2018 to December 2023, and had undergone transcranial color-coded Doppler (TCCD) examination. Follow-up was conducted until July 2025, with all-cause mortality defined as the primary endpoint. Results: A total of 790 non-dialysis CKD patients were included in the final analysis, of whom 361 (45.7%) had ICAS. Multivariate logistic regression analysis identified advanced age (odds ratio [OR] = 1.029), hypertension (OR = 3.758), diabetes mellitus (OR = 2.504), elevated fibrinogen (OR = 1.263), and lower hemoglobin (OR = 0.987,) as independent correlated factors of ICAS in non-dialysis CKD patients (all Conclusion: The prevalence of ICAS in non-dialysis CKD patients was 45.7%. Advanced age, hypertension, diabetes mellitus, elevated fibrinogen, and lower hemoglobin were independent correlated factors for ICAS. Advanced age, CKD stages 4-5, chronic heart disease, PCS, and lower corrected serum calcium were independent predictors of all-cause mortality in this population.
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