Evidence map›Paper›PMID 41929605›Full record

ArticleFrontiers in neurology

Effect of specific mode electroacupuncture stimulation combined with NGF on dysphagia after ischemic stroke: study protocol for a pilot randomized controlled trial.

Xiaoyang Yu, Ziqi Xuan, Zhaoxing Jia, Xuekang Niu, Yan Yan, Youmei Zhang, Lili Lin, Jingjing Li, Congcong Ma, Xianming Lin

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06737549 (Effect of Specific Mode Electroacupuncture Stimulation Combined with NGF on Dysphagia After Ischaemic Stroke), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06737549 phase4recruitingnot on this map

Effect of Specific Mode Electroacupuncture Stimulation Combined with NGF on Dysphagia After Ischaemic Stroke: a Pilot Randomized Controlled Trial

TypeinterventionalSponsorThe Third Affiliated hospital of Zhejiang Chinese Medical UniversityRan2024 to 2027Enrolled144ConditionsIschemic Stroke, DysphagiaArmsNerver growth factor (NGF) injection, Placebo injection, EA intervention, Acupuncture intervention
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoyang Yu *The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Ziqi Xuan *The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Zhaoxing Jia *The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Xuekang NiuThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Yan YanThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Youmei ZhangThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Lili LinThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Jingjing LiZhejiang Rehabilitation Medical Center, Hangzhou, Zhejiang, China.
Congcong MaThe Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Xianming LinThe Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Dysphagia is a major complication following ischemic stroke, but lacks effective treatments. Our previous studies show specific mode electroacupuncture stimulation (SMES) is an alternative approach to open the blood-brain barrier (BBB). Delivery of NGF across the BBB by SMES may be effective for treating dysphagia after ischemic stroke. The aim of this study is to assess the efficacy and safety of SMES combined with NGF for dysphagia after ischemic stroke. Methods: A total of 144 participants will be randomly assigned to an electroacupuncture (EA) + NGF group, an EA + placebo group, an acupuncture + NGF group, or an acupuncture + placebo group in a ratio of 1:1:1:1. Patients will receive 18 sessions of treatment for 6 weeks and a follow up of 6 weeks. The primary outcome is the Functional Oral Intake Scale (FOIS), and the secondary outcomes are the Dysphagia Outcome and Severity Scale (DOSS), the Penetration Aspiration Scale (PAS), the modified Rankin Scale (mRS), and the Modified Barthel Index (MBI). The functional near-infrared spectroscopy (fNIRS) will be applied to detect the changes in neurological function. Additionally, blinding and safety will also be assessed. All analysis will be performed based on intention-to-treat. Discussion: This trial will explore the feasibility and provide potential evidence for the effectiveness and safety of SMES combined with NGF for dysphagia after ischemic stroke. Clinical trial registration: https://www.clinicaltrials.gov/ct2/show/NCT06737549, identifier (NCT06737549).

Indexed as

blood–brain barrierdysphagia after ischemic strokenerve growth factorpilot randomized controlled trialspecific mode electroacupuncture stimulationstudy protocol

Identifiers

PMID41929605
PMCPMC13038540

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.