ArticleSAGE open medicine2026
The effect of preoperative tizanidine on postoperative pain and trismus following surgical removal of mandibular third molar: A randomized clinical trial.
Article in SAGE open medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pain and trismus are common complications that significantly impair quality of life after mandibular third molar surgery. This study investigated the efficacy of only one preoperative dose of oral tizanidine, a centrally acting muscle relaxant having analgesic properties, in reducing these outcomes. Methods: Forty patients who needed surgical removal of bilateral impacted mandibular third molars were selected for a split-mouth, triple-blind, randomized clinical trial. Each patient was randomly assigned to receive 4 mg tizanidine or a placebo 1 h before surgery on one side. In the other surgery, the contralateral side was treated alternatively. The Visual Analog Scale (VAS) was used for pain assessment, and trismus was measured by maximum mouth opening (MMO) in millimeters at Days 1, 3, and 7 post-surgery. Paired Results: Tizanidine group had significantly lower mean VAS pain scores compared to the placebo group on the first postoperative day (3.30 ± 0.87 vs 5.25 ± 1.02; Conclusions: A single dose of preoperative oral tizanidine provides a useful supplementary tool to diminish immediate postoperative pain and relieve trismus after surgical removal of mandibular third molars. Tizanidine can be included as an adjunct in multimodal techniques to improve patient comfort and recovery following oral surgeries.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.