ArticleFrontiers in neuroscience2026
State-specific disruptions of dynamic functional connectivity in young migraine without aura: a hidden Markov model approach.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Migraine is a common neurological disorder involving network-level dysfunction. Increasing evidence suggests that migraine involves network-level dysfunction and is associated with altered resting-state functional connectivity. Traditional static functional connectivity analyses are limited in capturing the temporal dynamics of large-scale brain networks. The Hidden Markov Model (HMM) provides an advanced analytical framework to identify discrete, recurrent brain states and characterize their temporal properties without the constraints of arbitrary windowing assumptions. Objective: To characterize dynamic functional connectivity alterations in young patients with migraine without aura (MWoA) using HMM and examine associations between dynamic state metrics and clinical disability. Methods: Resting-state fMRI data were obtained from 200 participants (100 young MWoA patients and 100 matched healthy controls). Using the Dosenbach 160 ROI template (cerebellum excluded; Results: Eleven robust dynamic brain states were identified. Compared with controls, migraine patients demonstrated increased FO and MDT in States 7 (dorsal attention network-dominant) and 9 (multisensory integration), alongside reduced values in sensorimotor states (States 3, 4, 8, 11). State 9 exhibited significant abnormalities in DMN-SC and DMN-VAN connectivity (FDR-corrected Conclusions: Young MWoA patients exhibit a dual-mode dysfunction in brain dynamics: heightened external vigilance (State 7) and impaired segregation of internal-external processing (State 9), accompanied by instability in baseline sensorimotor configurations. Prolonged dwelling in State 9 and its correlation with disability highlight this multisensory integration state as a potential biomarker of migraine-related functional impairment. These findings provide new insights into neurobiological mechanisms and support dynamic network-based therapeutic strategies.
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