ArticleInternational journal of chronic obstructive pulmonary disease2026
VE-VCO2 Slope During Cardiopulmonary Exercise Test Predicts Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study.
Article in International journal of chronic obstructive pulmonary disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cardiopulmonary Exercise Test (CPET) serves as an integrative assessment tool to evaluate cardiac function, respiratory responses, and neuromuscular capacity in patients with chronic obstructive pulmonary disease (COPD) during incremental cycling exercise. VE-VCO2 slope during CPET was not fully understood in predicting acute exacerbations of COPD (AECOPD). This study aims to establish a predictive model for AECOPD based on the VE-VCO2 slope. Methods: In total, 79 patients with COPD were recruited between 2013 and 2019. All participants underwent baseline pulmonary function tests and CPET and were followed up for 5 years thereafter. Independent two-sample Results: The AECOPD group contains 62 participants and the Non-AECOPD group contains 17 participants. Groups comparisons revealed significant differences in VE-VCO2 slope, age, BMI, FEV1%predicted, FEV1/FVC ratio, and EqCO2. Multivariate Cox regression analysis identified VE-VCO2 slope (OR = 1.19, 95% CI: 1.09-1.29, p < 0.001), age (OR = 1.05, 95% CI: 1.02-1.09, p = 0.005), and FEV1%predicted (OR = 0.96, 95% CI : 0.94-0.99, p = 0.015) as significant predictors of AECOPD. The ROC curve analysis results about the above predictors found that the AUC of VE-VCO2 slope is highest independently in 1 year, 3 years and 5 years, with the optimal cutoff values = 28.42 in 5 years (hazard ratio = 3.18, 95% CI: 1.639-6.2, p < 0.001). Conclusion: The stratification of VE-VCO2 slope ≥28.42 was an independent predictor of AECOPD. Our study established VE-VCO2 slope as a novel stratified clinical biomarker for predicting AECOPD.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.