ArticleLiver cancer2026
Physical Activity Improves Overall Survival in Patients with Hepatocellular Carcinoma.
Article in Liver cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Physical activity improves survival in various cancers, but its impact in patients with hepatocellular carcinoma (HCC) remains unexplored. We aimed to investigate the association between initiating moderate-to-vigorous physical activity (MVPA) after HCC diagnosis and overall survival among previously inactive patients. Methods: This retrospective cohort study used Korean National Health Insurance Service data from 21,035 adults diagnosed with HCC between 2010 and 2023 who were physically inactive before diagnosis and completed biennial health examinations pre- and post-diagnosis. MVPA initiation was assessed through standardized questionnaires. Primary outcome was all-cause mortality; secondary outcomes were cancer-specific and non-cancer-specific mortality. Cox models estimated adjusted hazard ratios and 95% confidence intervals. Results: Among 21,035 patients (mean age 62.1 years; 78.1% male), 5,639 (26.8%) initiated MVPA and 15,396 (73.2%) remained inactive. During follow-up, 7,122 deaths occurred. The 12-year cumulative mortality was lower with MVPA initiation versus remaining inactive (53.9% vs. 61.2%; adjusted HR, 0.86; 95% CI, 0.82-0.92). Consistent associations were observed in patients receiving curative treatment (HR, 0.86; 95% CI, 0.78-0.95), those without curative treatment (HR, 0.87; 95% CI, 0.81-0.93), patients with viral HCC (HR, 0.87; 95% CI, 0.81-0.93), nonviral HCC (HR, 0.86; 95% CI, 0.77-0.96), cirrhotic patients (HR, 0.86; 95% CI, 0.80-0.93), and non-cirrhotic patients (HR, 0.88; 95% CI, 0.81-0.96). Propensity score-matched analysis confirmed these findings (HR, 0.87; 95% CI, 0.82-0.92). Conclusion: Among physically inactive adults with HCC, initiating MVPA after diagnosis was associated with lower mortality compared with remaining inactive, suggesting that promoting physical activity should be considered in comprehensive HCC care.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.