SynthesisFrontiers in oncology2026
Prognostic role of statins in colorectal cancer: a systematic review and meta-analysis.
Synthesis in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
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Abstract
Background: Colorectal cancer (CRC) is a leading cause of global cancer incidence and mortality. While the anti-tumor potential of statins has gained increasing attention, their exact impact on patient prognosis remains controversial. This systematic review and meta-analysis aims to comprehensively assess the association between statin use and survival outcomes in patients with CRC. Methods: We systematically searched the PubMed, Embase, Cochrane Library, and Web of Science databases for studies published from inception until October 31, 2025, that compared the impact of statin use versus non-use on the prognosis of patients with CRC. The quality of the included studies was assessed using the Newcastle-Ottawa Scale. The effect of statins was measured using hazard ratios (HRs) with 95% confidence intervals (CIs), and a random-effects model was employed for all pooled analyses. Results: A total of 25 observational studies involving 179, 979 CRC patients were included. Statin use was significantly associated with reduced ACM (HR: 0.80; 95%CI: 0.74-0.86; P < 0.001) and CSM (HR: 0.77; 95%CI: 0.73-0.81; P < 0.001) in CRC patients. These benefits were consistently observed in both pre-diagnosis (ACM: HR = 0.78; CSM: HR = 0.78) and post-diagnosis statin use (ACM: HR = 0.83; CSM: HR = 0.75). However, no significant association was found between statin use and DFM (HR: 0.88; 95%CI: 0.60-1.29; P = 0.513) or RFM (HR: 1.01; 95%CI: 0.94-1.09; P = 0.831). Conclusion: Statin use is associated with a significant reduction in ACM and CSM among CRC patients. This benefit is consistently observed with both pre-diagnosis and post-diagnosis use, suggesting statins may serve as a potential intervention to improve prognosis in CRC patients.t. Systematic Review Registration: https://inplasy.com/, identifier INPLASY2025110064.
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