ArticleBrain communications2026
Juvenile myoclonic epilepsy heterogeneity uncovered: Z-mapped imaging endophenotypes of cortical and subcortical structures and their clinical, cognitive and psychiatric features.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
To identify imaging endophenotypes in juvenile myoclonic epilepsy using individualized Z-maps of cortical/subcortical regions and examine their relationships with cognitive, psychiatric and epilepsy-related variables. Sixty-two juvenile myoclonic epilepsy patients (aged 12-25 years) and 41 age- and sex-matched healthy controls underwent 3T MRI, neuropsychological assessment, psychiatric evaluation and clinical interviews. Cortical thickness and subcortical volumes were processed with FreeSurfer, adjusted for age, sex and brain volume. Kolmogorov-Smirnov tests were used to compare regional distributions. Z-scores were calculated relative to healthy controls, and K-means clustering identified endophenotypes. In juvenile myoclonic epilepsy, there were reduced subcortical volumes most prominently in motor-related thalamus (
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