ArticleBeilstein journal of nanotechnology2026
Nanocarrier-integrated multilayer films produced by 3D printing for improved skin adhesion and curcumin photostability.
Article in Beilstein journal of nanotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
This proof-of-concept study evaluated whether semi-solid extrusion (SSE) 3D printing could be used to fabricate multilayer topical films that simultaneously enhance skin bioadhesion and photoprotection of curcumin, a highly photolabile anti-inflammatory and antioxidant compound. The development of topical films for cutaneous delivery faces several challenges, including the need for strong skin adhesion and the protection of photolabile actives from light exposure. We hypothesized that multilayered films designed for the cutaneous delivery of curcumin and produced by SSE could address these limitations. To overcome its poor solubility and enhance bioadhesion, curcumin was encapsulated in polymeric nanocapsules (C-NCs), yielding a mean particle size of 218 ± 5 nm, a polydispersity index of 0.10 ± 0.02, a zeta potential of -11 ± 4 mV, and 100% encapsulation efficiency. Films were fabricated containing either C-NCs (F
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