ReviewFrontiers in oral health2026
An updated systematic review and meta-analysis of tooth loss in patients with periodontitis and the risk of mild cognitive impairment.
Review in Frontiers in oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
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Abstract
Objective: Conflicting evidence has shown a connection between tooth loss, periodontitis, and increased risk of mild cognitive impairment (MCI); thus, we conducted a meta-analysis to clarify this association. Materials and methods: PubMed, Embase, Web of Science, the Cochrane Library, and MEDLINE (up to March 2025) were searched. Cross-sectional and longitudinal studies were included. Fully-adjusted odds ratios (aORs) with the most severe form of periodontitis or tooth loss were pooled with a random effects model using STATA 18/MP software. Subgroup and sensitivity analyses were conducted to elucidate possible heterogeneity. Results: The meta-analysis of five studies showed that neither periodontitis nor tooth loss substantially increased MCI risk after full adjustment, with pooled aORs of 1.27 (95% CI: 0.87-1.86, Conclusion: Overall, periodontitis and tooth loss were not statistically associated with increased MCI risk. Whereas the association between severe periodontitis and significant tooth loss and MCI was statistically significant. Thus, severe periodontitis and significant tooth loss were linked to decreased cognitive function. Systematic Review Registration: PROSPERO CRD420251055491.
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