ArticleMolecular medicine reports2026
Uremic toxin p‑cresyl sulfate enhances the calcification of aortic valvular interstitial cells via klotho/sirtuin‑1 signaling.
Article in Molecular medicine reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Sirt1 attenuates calcific aortic valve disease by inhibiting ferroptosis and enhancing mitochondrial function via the activation of the Nrf2/HO‑1/FTH1 axis.International journal of molecular medicine · 2026Article
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8 authors.
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Abstract
Calcific aortic valve disease (CAVD), a valvular heart disease with severe complications, is common in patients with chronic kidney disease (CKD). P‑cresyl sulfate (PCS) is a protein‑binding uremic toxin that induces chronic inflammation. Klotho and sirtuin‑1 (SIRT1) represent potential therapeutic agents for mitigating CKD‑induced vascular calcifications. We hypothesized that PCS could enhance valvular interstitial cell (VIC) calcification, which could be modulated by klotho/SIRT1 signaling. Alizarin Red S staining, western blotting and immunohistochemical analysis were performed in order to examine calcification and klotho/SIRT1 signaling in isolated porcine VICs following various 7‑day treatments. VIC treatments included incubation with PCS (10 and 100
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