Evidence map›Paper›PMID 41930613›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Interactions between blood pressure variability, cerebral autoregulation, and covert cerebral small vessel disease in relation to cognitive performance in community-dwelling older adults.

Nai-Fang Chi, Li-Ning Peng, Chun-Jen Lin, Hao-Min Cheng, Chen-Huan Chen, Pei-Ning Wang, Chih-Ping Chung

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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Nai-Fang ChiDepartment of Neurology, School of Medicine, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan.ORCID 0000-0002-2204-4923
Li-Ning PengCenter for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chun-Jen LinDepartment of Neurology, School of Medicine, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan.
Hao-Min ChengInstitute of Public Health and Cardiovascular Research Center, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan.
Chen-Huan ChenInstitute of Public Health and Cardiovascular Research Center, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan.
Pei-Ning WangDepartment of Neurology, School of Medicine, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan.
Chih-Ping ChungDepartment of Neurology, School of Medicine, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan.

Funding

National Science and Technology Council of Taiwan 109-2314-B-075 -084National Science and Technology Council of Taiwan 110-2314-B-075-082National Science and Technology Council of Taiwan 110-2628-B-A49A-517National Science and Technology Council of Taiwan 111-2314-B-075 -001National Science and Technology Council of Taiwan 111-2628-B-A49A-501National Science and Technology Council of Taiwan 112-2628-B-A49-015National Science and Technology Council of Taiwan 113-2314-B-A49-071
6 · The paper itself

Abstract

introductionBoth increased blood pressure variability (BPV) and impaired cerebral autoregulation (CA) have been linked to cerebral small vessel disease (CSVD) and cognitive performance, but whether they independently or interactively influence cognition remains unclear.

methodsWe analyzed 300 community-dwelling participants. Dynamic CA, beat-to-beat BPV measures, and MRI-based CSVD markers were quantified. Multivariate linear regression and mediation analyses assessed the associations and interactions between CA, BPV, CSVD, and Montreal Cognitive Assessment (MoCA) scores.

resultsHigher BPV was associated with greater CSVD burden. A significant interaction between CA and BPV indicated that the negative association between BPV and MoCA scores was evident only under impaired CA. Mediation analyses demonstrated that BPV influenced MoCA score directly rather than through CSVD. DISCUSSION: Increased BPV and impaired CA interacted and are associated with poorer cognitive performance independently of detectable CSVD, suggesting a potential link between hemodynamic instability and cognitive vulnerability in community-dwelling older adults.

Indexed as

Blood PressureCerebral Small Vessel DiseasesCerebrovascular CirculationCognitionHomeostasisAgedAged, 80 and overFemaleHumansIndependent LivingMagnetic Resonance ImagingMaleMental Status and Dementia TestsNeuropsychological Testsblood pressure variabilitycerebral autoregulationcerebral small vessel diseasescognitive functionMontreal Cognitive Assessment

Identifiers

PMID41930613
PMCPMC13052213

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.