Evidence map›Paper›PMID 41931112›Full record

ArticleACS chemical biology2026

Discovery of Autophagy Modulators that Increase I1061T NPC1 Expression and Promote Cholesterol Efflux in Niemann-Pick Type C Patient-Derived Fibroblasts.

Maryna Salkovski, Andrea Arrieche Suarez, Qiwen Gao, Ryan S Hippman, Zoe A Petros, Melissa A Korkmaz-Vaisys, Erica M Gerlach, Yaneris M Alvarado-Cartagena, Thu T A Nguyen, Ivan Pavlinov and 4 more

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In one paragraph

Article in ACS chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maryna SalkovskiDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.
Andrea Arrieche SuarezChemical Biology Section, Molecular Targets Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Boyles St., Frederick, Maryland 21702, United States.
Qiwen GaoDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.
Ryan S HippmanDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.ORCID 0000-0002-5283-5902
Zoe A PetrosDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.
Melissa A Korkmaz-VaisysDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.ORCID 0000-0003-4234-8702
Erica M GerlachDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.
Yaneris M Alvarado-CartagenaDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.
Thu T A NguyenDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.
Ivan PavlinovChemical Biology Section, Molecular Targets Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Boyles St., Frederick, Maryland 21702, United States.
Olga IlnytskaDepartment of Animal Sciences, Rutgers University, New Brunswick, New Jersey 08901, United States.
Judith StorchDepartment of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey 08901, United States.
Stephanie M ColognaDepartment of Chemistry, University of Illinois Chicago, Chicago, Illinois 60607, United States.ORCID 0000-0002-3541-3361
Leslie N AldrichChemical Biology Section, Molecular Targets Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Boyles St., Frederick, Maryland 21702, United States.ORCID 0000-0001-8406-720X

Funding

Development of autophagy modulators for evaluation as a therapeutic strategy for Niemann-Pick Type CR01NS114413 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI COLOGNA, STEPHANIE M · 2020 to 2024
$2.0M
NINDS NIH HHS R01 NS114413
6 · The paper itself

Abstract

Autophagy, an evolutionarily conserved catabolic process, has been implicated as a potential therapeutic target in Niemann-Pick Type C (NPC) disease, a fatal lysosomal storage disorder. Our goal was to identify autophagy modulators that positively impact NPC-relevant phenotypes to further evaluate the role of autophagy in this disease. Using a phenotypic high-throughput screen for autophagy modulation and a subsequent secondary assay in homozygous I1061T NPC1 patient-derived fibroblasts, two compounds,

Indexed as

AutophagyCarrier ProteinsCholesterolFibroblastsMembrane GlycoproteinsNiemann-Pick Disease, Type CDrug DiscoveryHumansIntracellular Signaling Peptides and ProteinsNiemann-Pick C1 ProteinCarrier ProteinsCholesterolIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsNiemann-Pick C1 ProteinNPC1 protein, human

Identifiers

PMID41931112
PMCPMC13097081

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.