Evidence map›Paper›PMID 41931252›Full record

ArticleThe Journal of physiology2026

Exercise training induces mitochondrial biogenesis, while high-fat diet increases the ability of mitochondria to use long and short-chain fatty acids.

Jessica L Dowling, Rachel M Handy, Nicole M Notaro, Sara M Frangos, David J Dyck, Graham P Holloway

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jessica L DowlingDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.ORCID 0009-0006-9297-8218
Rachel M HandyDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.ORCID 0000-0002-2996-1791
Nicole M NotaroDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.ORCID 0000-0003-3028-0544
Sara M FrangosDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.ORCID 0000-0002-1590-8826
David J DyckDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.ORCID 0000-0002-9253-3896
Graham P HollowayDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.ORCID 0000-0002-5019-4822

Funding

Natural Sciences and Engineering Research Council of Canada 400362
6 · The paper itself

Abstract

Short-chain fatty acids (SCFAs), derived from peroxisomal metabolism and the gut microbiota, have been proposed as key substrates to support mitochondrial oxidative phosphorylation (OXPHOS) in extrahepatic tissues such as skeletal muscle. However, the extent to which mitochondria can oxidize SCFAs (acetate, propionate and butyrate) and the ability of exercise training and a high-fat diet (HFD) to modulate this process remains unclear. Here, we show that SCFA-supported respiration in skeletal muscle is relatively limited (18 ± 6 nmol min

Indexed as

Diet, High-FatFatty AcidsFatty Acids, VolatileMitochondria, MuscleOrganelle BiogenesisPhysical Conditioning, AnimalAnimalsMaleMiceMice, Inbred C57BLMuscle, SkeletalOxidative PhosphorylationFatty AcidsFatty Acids, Volatileexercisehigh‐fat dietmitochondriashort‐chain fatty acidsskeletal muscle

Identifiers

PMID41931252
PMCPMC13082196

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.