ArticleMedicine2026
Genetically determined causality between immune cells and anxiety disorders: A Mendelian randomization study.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Migraine immune cell gene targets and their relationship to psychiatric disorders.The journal of headache and pain · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Prior investigations have endeavored to unveil the connection between immune cells and anxiety disorders. However, the majority are limited to a single or few indicators and have not comprehensively evaluated the causal relationship between immune cells and anxiety disorders. In this study, we performed a two-sample Mendelian randomization (MR) analysis to assess the relationship between 731 immune phenotypes and anxiety disorders, offering genetic evidence to substantiate the correlation between immune phenotypes and the risk of anxiety disorders. Using publicly available data from genome-wide association studies on immune phenotypes and anxiety disorders, we selected instrumental variables that met specified criteria. Employing inverse-variance weighting and MR-Egger regression analysis methods, we assessed the causality between 731 immune cell factors and the risk of anxiety disorders. MR-Egger intercept tests, Cochran Q tests, and leave-one-out sensitivity analyses were performed to ascertain the pleiotropy, heterogeneity, and stability of the genetic variations. The primary MR method (inverse-variance weighting) analysis revealed a significant causal correlation between 32 immune phenotypes and anxiety disorders. Following multivariable MR adjustments, 5 exposure factors demonstrated a significant association with anxiety disorders: CD80 on myeloid dendritic cell (odds ratio [OR] = 1.05, 95% confidence interval [CI] = 1.00-1.10, P = .010), CD39+ CD8+ T cell %T cell (OR = 0.98, 95% CI = 0.97-1.00, P = .032), CD39+ CD8+ T cell absolute count (OR = 0.98, 95% CI = 0.97-1.00, P = .025), human leukocyte antigen-DR isotype on monocyte (OR = 0.97, 95% CI = 0.94-0.99, P = .013), CD4 on naive CD4+ T cell4 (OR = 0.95, 95% CI = 0.91-1.00, P = .048). Reverse MR suggested an impact of anxiety disorders on 21 immune phenotypes. Our study established an association between immune phenotypes and anxiety disorders, offering a novel avenue for exploring and gaining deeper insights into the pathogenic mechanisms of anxiety disorders. Additionally, these findings provide an immunological perspective that could be valuable for the clinical diagnosis and intervention of anxiety disorders.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.