Evidence map›Paper›PMID 41932308›Full record

ArticleMolecular cell2026

The HIF-2 transcription factor mediates resistance to ferroptosis in pancreatic cancer.

Maimon E Hubbi, Catherine L Wang, Yasir Suhail, Nadia L Almasri, Jane Xie, Erin E Hollander, Kshitiz, Alexander Muir, Ben Z Stanger, Chi V Dang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maimon E HubbiDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Ludwig Institute for Cancer Research, New York, NY, USA. Electronic address: mhubbi1@jhmi.edu.
Catherine L WangDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Ludwig Institute for Cancer Research, New York, NY, USA; Medical Scientist Training Program, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Yasir SuhailDepartment of Biomedical Engineering, University of Connecticut Health, Farmington, CT, USA.
Nadia L AlmasriDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jane XieDepartment of Medicine and Abramson Cancer Center and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Erin E HollanderDepartment of Medicine and Abramson Cancer Center and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Medical Scientist Training Program, University of Pennsylvania, Philadelphia, PA, USA.
KshitizDepartment of Biomedical Engineering, University of Connecticut Health, Farmington, CT, USA.
Alexander MuirBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA.
Ben Z StangerDepartment of Medicine and Abramson Cancer Center and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Chi V DangDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Ludwig Institute for Cancer Research, New York, NY, USA; Department of Biochemistry & Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: cvdang@jhmi.edu.

Funding

C-MYC TARGETS IN THE PATHOGENESIS OF HUMAN CANCERSR01CA057341 · NCI · WISTAR INSTITUTE · PI DANG, CHI V. · 1992 to 2021
$8.3M
MYC--TRANSCRIPTION AND INTERACTION WITH P107R01CA051497 · NCI · WISTAR INSTITUTE · PI DANG, CHI V. · 1995 to 2025
$5.3M
Defining metabolic adaptations within the PDAC "arid" tumor microenvironmentR01CA252225 · NCI · WISTAR INSTITUTE · PI DANG, CHI V., STANGER, BEN Z · 2021 to 2025
$2.8M
Investigating the Role of Emergent Oscillations of Hypoxia Inducible Factor-1 alpha Activity in Cancer Growth and ProgressionR37CA248161 · NCI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KSHITIZ, . · 2020 to 2025
$2.5M
Defining the role of Acss2 in T cell adaptation to metabolic stressF30CA301757 · NCI · JOHNS HOPKINS UNIVERSITY · PI Catherine Wang · 2025 to 2026
$110k
NCI NIH HHS F30 CA301757NCI NIH HHS R01 CA051497NCI NIH HHS R01 CA057341NCI NIH HHS R01 CA252225NCI NIH HHS R37 CA248161
6 · The paper itself

Abstract

Ferroptosis is an iron-dependent form of cell death converging on lipid peroxidation first identified by examining compounds with enhanced lethality to KRAS mutant cells. Despite over 90% of pancreatic ductal adenocarcinoma (PDAC) tumors harboring KRAS mutations, PDAC exhibits relative resistance to ferroptosis compared with other tumor types, and the mechanisms behind this resistance remain unclear. Here, we report that exposure to pancreatic tumor interstitial fluid in synergy with hypoxia induced robust protection against ferroptosis in a manner dependent on the hypoxia-inducible transcription factor 2 (HIF-2). HIF-2 upregulates the expression of both components of the system Xc

Indexed as

Basic Helix-Loop-Helix ProteinsCarcinoma, Pancreatic DuctalFerroptosisPancreatic NeoplasmsAmino Acid Transport System y+AnimalsCell Line, TumorCysteineEndothelial PAS Domain-Containing Protein 1Gene Expression Regulation, NeoplasticGlutathioneHumansMitochondriaMitophagyReactive Oxygen SpeciesSignal TransductionAmino Acid Transport System y+Basic Helix-Loop-Helix ProteinsCysteineEndothelial PAS Domain-Containing Protein 1GlutathioneReactive Oxygen SpeciesSLC7A11 protein, humanferroptosisHIF-2 transcription factorhypoxiapancreatic ductal adenocarcinoma

Identifiers

PMID41932308
PMCPMC13052133

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.