ArticleJournal of magnetic resonance imaging : JMRI2026
Multimodal MR Imaging Reveals the Mechanisms of Post-Cardiac-Arrest Brain edema: Ferroptosis-Mediated BBB Disruption and AQP4 Dysfunction.
Article in Journal of magnetic resonance imaging : JMRI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Editorial for "Multimodal MR Imaging Reveals the Mechanisms of Post-Cardiac-Arrest Brain edema: Ferroptosis-Mediated BBB Disruption and AQP4 Dysfunction".Journal of magnetic resonance imaging : JMRI · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe role of ferroptosis in Cardiac arrest (CA)-induced cerebral edema remains unclear. PURPOSE: To investigate whether ferroptosis contributes to blood-brain barrier (BBB) disruption and aquaporin-4 (AQP4) dysfunction following CA. STUDY TYPE: Prospective. ANIMAL MODEL: Asphyxia-induced CA rat model. Forty two rats were used and assigned to the CA (24) and the sham (18) group. FIELD STRENGTH/SEQUENCE: T2-weighted anatomical imaging with 2D turbo spin-echo sequence, QSM with 3D GRE sequence, IVIM with 2D RESOLVE EPI sequence, ASSESSMENT: Multiparametric MRI was performed 24 h after return of spontaneous circulation (ROSC). Imaging findings were validated using histology, immunohistochemistry, Western blot, and transmission electron microscopy. STATISTICAL TESTS: Unpaired two-tailed Student's T-test was used. A p value less than 0.05 was considered statistically significant.
resultsCA led to marked neurological deficits, although no obvious abnormalities were observed on T DATA
conclusionThis study provides evidence for a sequential cascade after CA and ROSC in which iron overload is associated with ferroptosis, which is linked to disruption of the blood-brain barrier. This barrier disruption coincides with AQP4 depolarization, inducing cytotoxic and vasogenic edema, which, along with depolarization, is accompanied by neuronal death. Multimodal MRI noninvasively captures this process, offering an early detection and monitoring platform for ferroptosis-related brain injury and underscoring its potential as a translational tool for neuroprotective interventions. EVIDENCE LEVEL: 1. TECHNICAL EFFICACY: Stage 1.
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Registered trials
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