Evidence map›Paper›PMID 41933730›Full record

ArticleThe Journal of biological chemistry2026

Cell type-specific control of cardiometabolic disease by the dileucine motif of the LDL receptor-related protein LRP1.

Emily Igel, Anja Jaeschke, April Haller, Melissa Asman, Ushodaya Mattam, Jeyashree Alagarsamy, Karthickeyan Chella Krishnan, David Y Hui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emily IgelDepartment of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Anja JaeschkeDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio USA.
April HallerDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio USA.
Melissa AsmanDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio USA.
Ushodaya MattamDepartment of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Jeyashree AlagarsamyDepartment of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA; Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio USA.
Karthickeyan Chella KrishnanDepartment of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
David Y HuiDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio USA. Electronic address: huidy@ucmail.uc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The LDL receptor-related protein-1 (LRP1) modulates cardiometabolic diseases in a cell type-specific manner and is regulated via several motifs in its cytoplasmic domain. This study compared the cardiometabolic disease phenotype of Ldlr

Indexed as

AtherosclerosisLow Density Lipoprotein Receptor-Related Protein-1Amino Acid MotifsAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutReceptors, LDLLow Density Lipoprotein Receptor-Related Protein-1Lrp1 protein, mouseReceptors, LDLatherosclerosislipoprotein metabolismlipoprotein receptor-related protein (LRP)macrophageperoxisomal proliferator-activated receptor (PPAR)

Identifiers

PMID41933730
PMCPMC13129387

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.