Evidence map›Paper›PMID 41933894›Full record

ArticleThe New phytologist2026

Ligand-induced ubiquitination regulates endocytosis and homeostasis of the ERECTA receptor kinase for stomatal development.

Liangliang Chen, Minh Huy Vu, Pengfei Bai, Alicia M Cochran, Crystal F Ying, Keiko U Torii

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The New phytologist, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. ERECTA-family receptor kinases: versatile regulators of plant developmental signaling.The Plant journal : for cell and molecular biology · 2026
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Liangliang Chen *Howard Hughes Medical Institute, The University of Texas at Austin, Austin, TX, 78712, USA.ORCID https://orcid.org/0000-0001-5740-7221
Minh Huy Vu *Howard Hughes Medical Institute, The University of Texas at Austin, Austin, TX, 78712, USA.ORCID https://orcid.org/0000-0002-1963-2759
Pengfei BaiHoward Hughes Medical Institute, The University of Texas at Austin, Austin, TX, 78712, USA.ORCID https://orcid.org/0000-0002-2281-2881
Alicia M CochranHoward Hughes Medical Institute, The University of Texas at Austin, Austin, TX, 78712, USA.
Crystal F YingDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX, 78712, USA.ORCID https://orcid.org/0009-0007-8318-9142
Keiko U ToriiHoward Hughes Medical Institute, The University of Texas at Austin, Austin, TX, 78712, USA.ORCID https://orcid.org/0000-0002-6168-427X

Funding

Howard Hughes Medical InstituteThe University of Texas at Austin
6 · The paper itself

Abstract

Stomatal patterning on the plant epidermis is regulated by the ERECTA family of leucine-rich repeat receptor kinases (LRR-RKs). While ubiquitination has emerged as a key regulatory mechanism for the endocytosis of receptor kinases, the precise molecular connections among ERECTA ubiquitination, endocytosis, and its biological functions remain unclear. Here, we uncover a critical role of ligand-induced ubiquitination in regulating the endocytosis and homeostasis of the ERECTA receptor kinase for stomatal development and elongation of inflorescence pedicels in Arabidopsis thaliana. Previous ubiquitome profiling of plant membrane proteins identified one ubiquitination site in ERECTA, and our sequence alignment analysis identified two additional ubiquitination sites within the juxtamembrane domain. We subsequently performed site-directed mutagenesis of these lysine residues (K617, K625, and K668) to arginine (ERECTA

Indexed as

ArabidopsisArabidopsis ProteinsEndocytosisHomeostasisPlant StomataProtein Serine-Threonine KinasesReceptors, Cell SurfaceUbiquitinationAmino Acid SequenceLigandsLysineMutationArabidopsis ProteinsER protein, ArabidopsisLigandsLysineProtein Serine-Threonine KinasesReceptors, Cell Surfaceendocytosisinflorescence/pedicel elongationpeptide hormonereceptor kinasestomatal developmentubiquitination

Identifiers

PMID41933894
PMCPMC13150308

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.