ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Liver metastases represent an urgent unmet medical need in the care of cancer due to a lack of effective therapies. This study reveals that pathological ammonia accumulation, resulting from dysregulation of ammonia removal processes, promotes the formation of a hepatic microenvironment favorable for metastatic colonization. Metabolomic and transcriptomic analyses suggest that tumoral metabolic reprogramming due to cancer cell-intrinsic hyperactivation of the de novo pyrimidine biosynthesis pathway impairs the urea cycle and causes pathological ammonia accumulation. Utilizing tumor microenvironmental profiling and single-cell RNA sequencing, subsequent analyses further reveal that ammonia accumulation remodels the hepatic stromal-immune landscape by inducing hepatic stellate cell differentiation into metastasis-associated fibroblasts (MAFs), suppressing Ifi27l2a
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.