Evidence map›Paper›PMID 41934203›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2026

Murine Progeria Model Exhibits Delayed Fracture Healing With Senescent Phenotype and Dysregulated Immune Response.

Victoria R Duke, Marc J Philippon, Dane R G Lind, Herbert Kasler, Kohei Yamaura, Matt Huard, Molly Czachor, Justin Hollenbeck, Justin Brown, Alex Garcia and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Murine Progeria Model Exhibits Delayed Fracture Healing With Senescent Phenotype and Dysregulated Immune Response.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Victoria R DukeSteadman Philippon Research Institute, Vail, Colorado, USA.
Marc J PhilipponSteadman Philippon Research Institute, Vail, Colorado, USA.
Dane R G LindSteadman Philippon Research Institute, Vail, Colorado, USA.
Herbert KaslerBuck Institute for Research on Aging, Novato, California, USA.
Kohei YamauraSteadman Philippon Research Institute, Vail, Colorado, USA.
Matt HuardSteadman Philippon Research Institute, Vail, Colorado, USA.
Molly CzachorSteadman Philippon Research Institute, Vail, Colorado, USA.
Justin HollenbeckSteadman Philippon Research Institute, Vail, Colorado, USA.
Justin BrownSteadman Philippon Research Institute, Vail, Colorado, USA.
Alex GarciaSteadman Philippon Research Institute, Vail, Colorado, USA.
Jacob D MatityahuUniversity of California, San Francisco, California, USA.
Naomasa FukaseSteadman Philippon Research Institute, Vail, Colorado, USA.
Ralph S MarcucioUniversity of California, San Francisco, California, USA.
Anna-Laura NelsonSteadman Philippon Research Institute, Vail, Colorado, USA.
William S HambrightSteadman Philippon Research Institute, Vail, Colorado, USA.
Dustin M SnapperSteadman Philippon Research Institute, Vail, Colorado, USA.
Johnny HuardSteadman Philippon Research Institute, Vail, Colorado, USA.
Chelsea S BahneySteadman Philippon Research Institute, Vail, Colorado, USA.ORCID 0000-0001-9808-8888

Funding

Skeletal Biology and Biomechanics (SBB) CoreP30AR075055 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 2019 to 2026
$7.1M
Therapeutic Application of Painless Nerve Growth Factor to Accelerate Endochondral Fracture RepairR01AR077761 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BAHNEY, CHELSEA SHIELDS · 2021 to 2025
$3.2M
NIH HHS P30AR075055NIH HHS R01AR077761Orthopaedic Trauma Association 6763
6 · The paper itself

Abstract

An estimated 189 million bone fractures occurred in 2019 making it one of the most globally prevalent injuries. Delayed union or nonunion occurs in up to 15% of normal fractures with higher rates in aged individuals. Preclinical testing supports the translation of novel strategies to promote improved fracture repair, but there is a paucity of small animal models that recapitulate delayed fracture healing. Here, we evaluated the Zmpste24

Indexed as

Fracture HealingProgeriaTibial FracturesAgingAnimalsDisease Models, AnimalFemaleMaleMembrane ProteinsMetalloendopeptidasesMiceMice, Inbred C57BLPhenotypeMembrane ProteinsMetalloendopeptidasesZmpste24 protein, mouseanimal modeldelayed unionfracture repairimmunophenotypingnon‐unionprogeria

Identifiers

PMID41934203
PMCPMC13049502

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.