Evidence map›Paper›PMID 41934285›Full record

Trial reportObesity (Silver Spring, Md.)2026

Effects of a 2-Year Primary Care Weight Loss Intervention on Quality of Life in Patients With Obesity.

Kara D Denstel, Emily F Mire, Corby K Martin, John W Apolzan, Connie L Arnold, Terry C Davis, Carl J Lavie, Robert L Newton, Dachuan Zhang, Eboni G Price-Haywood and 2 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity (Silver Spring, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02561221 (Promoting Successful Weight Loss in Primary Care in Louisiana), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02561221 nacompletednot on this map

Promoting Successful Weight Loss in Primary Care in Louisiana

TypeinterventionalSponsorPennington Biomedical Research CenterRan2016 to 2019Enrolled803ConditionsObesityArmsLifestyle Counseling
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kara D DenstelPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Emily F MirePennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Corby K MartinPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
John W ApolzanPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0001-8492-7820
Connie L ArnoldDepartment of Medicine and Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA.
Terry C DavisDepartment of Medicine and Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA.
Carl J LavieDepartment of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, New Orleans, Louisiana, USA.
Robert L NewtonPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Dachuan ZhangPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Eboni G Price-HaywoodOchsner Clinical School-University of Queensland School of Medicine, New Orleans, Louisiana, USA.
Peter T KatzmarzykPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0002-9280-6022
PROPEL Research Group

Funding

Louisiana Clinical and Translational Science CenterU54GM104940 · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2025 to 2025
$3.9M
Pilot and Feasibility ProgramP30DK072476 · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2005 to 2025
$2.2M
NIDDK NIH HHS P30 DK072476NIDDK NIH HHS P30DK072476NIGMS NIH HHS U54 GM104940NIGMS NIH HHS U54GM104940Patient-Centered Outcomes Research Institute OB-1402-10977
6 · The paper itself

Abstract

objectiveThis study examined (1) the association between weight loss and changes in health-related quality of life (HRQoL) and (2) treatment response heterogeneity among patients in a weight loss intervention.

methodsEighteen primary care clinics were randomized to a 24-month intensive lifestyle intervention or usual care. Generic HRQoL and weight-related QoL were assessed at baseline and months 6, 12, and 24. Associations were analyzed using repeated-measures linear multilevel models.

resultsThe sample included 803 patients with obesity. Changes in generic HRQoL did not differ by race or sex, and weight-related QoL did not differ by sex. However, Black patients experienced less improvement in weight-related QoL compared to other races. There was a graded association between improvements in weight-related QoL and greater weight loss between baseline and 24 months: 7.4 (95% CI: 5.1, 9.7) for those who lost < 5% of their initial body weight, 15.0 (11.4, 18.5) for 5% to < 10% weight loss, and 18.9 (15.4, 22.4) for ≥ 10% weight loss. Greater weight loss was also related to greater improvements in most generic HRQoL domains.

conclusionsWeight loss was associated with improvements in HRQoL, and race differences were identified in changes in weight-related QoL, highlighting the need for precision medicine approaches to weight loss.

trial registrationClinicalTrials.gov identifier NCT02561221.

Indexed as

ObesityQuality of LifeWeight LossWeight Reduction ProgramsAdultFemaleHumansLife StyleMaleMiddle AgedPrimary Health CareTreatment Effect HeterogeneityTreatment Outcomepatient‐reported outcomestreatment effect heterogeneitywell‐being

Identifiers

PMID41934285
PMCPMC13387151

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.