Evidence map›Paper›PMID 41934458›Full record

ArticleJACC. Case reports2026

Atypical Presentations of Coronary Microvascular Dysfunction in Patients After COVID.

Nisarg Ray, Ahan Kayastha, Krunal Shukla, Michael Massoomi, Ellen C Keeley, Natalie Bracewell

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nisarg RayDepartment of Medicine, University of Florida, Gainesville, Florida, USA.
Ahan KayasthaDepartment of Medicine, University of Florida, Gainesville, Florida, USA.
Krunal ShuklaDepartment of Medicine, University of Florida, Gainesville, Florida, USA.
Michael MassoomiDepartment of Medicine, University of Florida, Gainesville, Florida, USA; Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida, USA.
Ellen C KeeleyDepartment of Medicine, University of Florida, Gainesville, Florida, USA; Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida, USA.
Natalie BracewellDepartment of Medicine, University of Florida, Gainesville, Florida, USA; Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida, USA. Electronic address: natalie.bracewell@medicine.ufl.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronary microvascular dysfunction is a recognized cause of angina without obstructive coronary disease, yet routine tests are often nondiagnostic. In this case series, we describe 3 previously active adults with persistent chest pain after SARS-CoV-2 infection who fulfilled the World Health Organization criteria for postacute sequelae. All 3 patients underwent invasive coronary angiography with coronary reactivity testing with coronary flow reserve (CFR). In all patients, the epicardial coronary arteries were angiographically normal, however CFR was significantly impaired (<2.0). Medical management was tailored and guideline-concordant, including the use of calcium-channel blockers, beta-blockers, long-acting nitrates, and graded exercise, with some improvement in symptoms. We contend that coronary microvascular dysfunction may be the etiology of post-COVID chest pain. An earlier CFR assessment may shorten diagnostic delays and improve quality of life.

Indexed as

cardiovascular diseasechest paincomplicationcoronary angiographycoronary circulationechocardiographyexercise

Identifiers

PMID41934458
PMCPMC13154094

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.