Evidence map›Paper›PMID 41934491›Full record

ReviewNeuromolecular medicine2026

SIRT1 Activators as Geroprotective Agents in Brain Aging: Mechanisms and Therapeutic Potential.

Ayman Ali Mohammed Alameen, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Athanasios Alexiou, Marios Papadakis, Safaa A Faheem, Gaber El-Saber Batiha

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuromolecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ayman Ali Mohammed AlameenDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, P.O. Box 2014, Sakaka, Saudi Arabia.ORCID 0000-0002-8467-9692
Hayder M Al-KuraishyDepartment of Clinical Pharmacology and Medicine, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq.
Ali I Al-GareebDepartment of Clinical Pharmacology and Medicine, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq.
Athanasios AlexiouEuropean Academy of Sciences and Arts, Vienna, Austria.ORCID 0000-0002-2206-7236
Marios PapadakisMedical Department, Faculty of Life Sciences, University of Thessaly, 3 Panepistimiou Str., Viopolis, 41500, Larissa, Greece. mapapadakis@uth.gr.ORCID 0000-0002-9020-874X
Safaa A FaheemDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo-Suez Road, Badr City, Cairo, 11829, Egypt. safaa-faheem@eru.edu.eg.ORCID 0000-0002-1827-6131
Gaber El-Saber BatihaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhur University, Damanhur, AlBeheira, 22511, Egypt. Gaberelsaberbatiha@gmail.com.ORCID 0000-0002-7817-425X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The brain undergoes profound molecular and structural changes during the aging process, resulting in the development of neurodegeneration, cognitive impairment, and increased vulnerability to chronic diseases. At the cellular level, brain aging is characterized by oxidative damage, genomic instability, and chronic low-grade inflammation known as inflammaging. Central to this process is Sirtuin 1 (SIRT1), a NAD

Indexed as

AgingBrainEnzyme ActivatorsNeuroprotective AgentsSenotherapeuticsSirtuin 1AnimalsAutophagyCellular SenescenceHumansNeurodegenerative DiseasesOxidative StressSignal TransductionEnzyme ActivatorsNeuroprotective AgentsSenotherapeuticsSIRT1 protein, humanSirtuin 1Brain agingGeroprotectorsNeuroinflammationOxidative stressSIRT1

Identifiers

PMID41934491
PMCPMC13050347

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.