Evidence map›Paper›PMID 41935313›Full record

ArticleAnimal microbiome2026

Integrative multi-omics analysis identifies C-type lectin CNVs as functional targets for breeding mastitis-resistant dairy goats.

Ying Yuan, He Cong, Tao Ren, Peng-Cheng Ruan, Lu Xu, Bai-Gao Yang, Hao-Yuan Zhang, Simone Ceccobelli, Zi-Xuan Wang, Yao-Long Liu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal microbiome, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ying YuanCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.
He CongCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.
Tao RenCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.
Peng-Cheng RuanCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.
Lu XuCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.
Bai-Gao YangCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.
Hao-Yuan ZhangCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.
Simone CeccobelliAnimal Breeding and Genetics Department of Agricultural, Food and Environmental Sciences, Università Politecnica delle Marche, 10-60131, Ancona, Italy.
Zi-Xuan WangCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.
Yao-Long LiuCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.
KaushalendraDepartment of Zoology, Pachhunga University College, Mizoram University, Aizawl, 796001, India.
Yan-Guo HanCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.
Yan ZengCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.
Hong MiaoCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.
De-Jun XuCollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China.
Guang-Xin ECollege of Animal Science and Technology, Southwest University, Chongqing, 400715, China. eguangxin@126.com.

Funding

National Natural Science Foundation of China 32272834
6 · The paper itself

Abstract

Mastitis poses a critical challenge to dairy goat production, impacting animal welfare, milk yield, and the microbiological safety of dairy products. This study employed a multi-omics approach to explore the genetic basis of mastitis resistance in Saanen goats, focusing on identifying functional copy number variants (CNVs) and their roles in immune regulation. A genome-wide scan identified 62,860 CNVs, with 115 exhibiting strong selection signals. Among these, two adjacent CNVs overlapping with the C-type lectin genes LOC108636060 and LOC108636138 were noteworthy due to their high deletion frequencies in the population of Saanen goats. Functional investigations involving lipopolysaccharide (LPS)-challenged goat mammary epithelial cells (GMECs) demonstrated that the overexpression of these two C-type lectin genes significantly potentiated NF-κB signaling pathway activation. This was accompanied by the marked upregulation of key inflammatory mediators, including CD14, CXCL8, and PTGS2. Integrated metabolomic analysis further validated their involvement in modulating immune-associated metabolic responses, such as alterations in lipid metabolism, amino acid derivatives, and inflammatory signaling molecules. These findings indicate that LOC108636060 and LOC108636138 could contribute to mastitis resistance through the regulation of innate immune pathways, with critical roles in orchestrating inflammatory responses. Their functional relevance suggests these genes may serve as promising candidates for selective breeding programs. Incorporating these markers into breeding strategies could facilitate the improvement of udder health, bolster mastitis resistance, and contribute to the overall safety of milk products in dairy goat production.

Indexed as

Copy number variantC-type lectinDairy goatInnate immunityMastitis resistanceMilk safety

Identifiers

PMID41935313
PMCPMC13188593

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.