ArticleJournal of animal science and biotechnology2026
Hesperidin alleviates systemic inflammation and oxidative stress by remodeling adipose tissue lipid metabolism in periparturient dairy cows.
Article in Journal of animal science and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Laminitis in Holstein dairy cows is associated with intestinal and mammary dysfunction, systemic inflammation, and microbiota dysregulation.Frontiers in microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundPeriparturient dairy cows experience a pronounced negative energy balance that accelerates adipose tissue lipolysis and predisposes them to oxidative stress and inflammation. Plant flavonoids such as hesperidin are known for their antioxidant and immunomodulatory properties, yet their specific actions on adipose tissue metabolism during the transition period remain unclear. This study evaluated whether dietary hesperidin improves milk composition and systemic metabolic health while remodeling adipose tissue lipid metabolism in periparturient cows.
resultsHesperidin supplementation enhanced milk composition by increasing protein concentration and yield and lowering milk urea nitrogen, while dry matter intake and milk production were unaffected. In serum, hesperidin reduced non-esterified fatty acid, β-hydroxybutyrate, glucose, and insulin, and elevated adiponectin, leading to improved insulin sensitivity. Antioxidant capacity was strengthened, and several proinflammatory mediators, including IL-18, TNF-α, serum amyloid A, lipopolysaccharide-binding protein, caspase-1, and ASC, were significantly reduced. Three HES-derived metabolites (hesperetin-7-O-glucuronide, hesperetin, and hesperetin-7-O-sulfate) in serum and adipose tissue were detected. In adipose tissue, hesperidin increased total antioxidant capacity and superoxide dismutase activity and downregulated IL-18, NLRP3, and ASC, while adiponectin was elevated, indicating enhanced redox defenses and reduced inflammasome activation. Multi-omics analyses revealed consistent remodeling of adipose metabolism. Metabolomics and lipidomics showed decreased ceramides and acylcarnitines, together with increased sphingomyelins and glycerophospholipids, patterns that were also evident in serum lipid profiles. Proteomics further supported these findings by indicating upregulation of pathways related to fatty acid oxidation, mitochondrial function, and phospholipid and glutathione metabolism, alongside suppression of sphingolipid and innate immune signaling.
conclusionsDietary hesperidin improved milk protein output and systemic metabolic health, enhanced antioxidant capacity, and alleviated inflammatory responses during the transition period. Integrated omics evidence indicates that hesperidin reprograms adipose lipid metabolism-particularly sphingolipid pathways-toward lower ceramide burden and higher sphingomyelin, while reinforcing mitochondrial and antioxidant functions. These adaptations highlight the potential of hesperidin as a nutritional strategy to improve adipose tissue function and whole-body metabolic homeostasis in periparturient cows.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.