Evidence map›Paper›PMID 41935441›Full record

ArticleRedox biology2026

Reactive sulfur species are inactivated and excreted as trimethylsulfonium ion by thiopurine S-methyltransferase.

Yasunori Fukumoto, Momoka Uchida, Yoshikazu Yamagishi, Natsu Saito, Ayune Watanabe, Rina Mukasa, Ryosuke Kobayashi, Takuro Horii, Izuho Hatada, Yu-Ki Tanaka and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yasunori FukumotoGraduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.
Momoka UchidaGraduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.
Yoshikazu YamagishiGraduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Natsu SaitoGraduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.
Ayune WatanabeGraduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.
Rina MukasaGraduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.
Ryosuke KobayashiLaboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, 371-8512, Japan; Laboratory of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, 069-8501, Japan.
Takuro HoriiLaboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, 371-8512, Japan.
Izuho HatadaLaboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, 371-8512, Japan; Viral Vector Core, Gunma University Initiative for Advanced Research (GIAR), Maebashi, 371-8511, Japan.
Yu-Ki TanakaGraduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.
Noriyuki SuzukiGraduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.
Yasumitsu OgraGraduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan. Electronic address: ogra@chiba-u.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactive sulfur species (RSS) play essential roles in cellular signaling, redox regulation, and defense against electrophilic stress. However, excessive RSS are cytotoxic and must be strictly regulated. While RSS elimination has been canonically attributed to oxidative pathways, here we show that thiopurine S-methyltransferase (TPMT), a selenium-associated methyltransferase, promotes the detoxification and urinary excretion of RSS. In a mouse model, knockout of TPMT decreased urinary excretion of the trimethylsulfonium, suggesting that TPMT catalyzes a non-oxidative elimination of RSS via methylation. Cell-based assays demonstrated that TPMT exerts a protective effect against excess RSS. In vitro, TPMT methylated hydrosulfide, polysulfides (HSS

Indexed as

MethyltransferasesSulfonium CompoundsSulfurAnimalsHumansMethylationMiceMice, KnockoutOxidation-ReductionMethyltransferasesSulfonium CompoundsSulfurthiopurine methyltransferaseMethyltransferaseReactive sulfur speciesSelenium metabolismSulfur methylationThiol redox chemistry

Identifiers

PMID41935441
PMCPMC13089183

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.