ArticleEnvironmental science & technology2026
Mismatch-Driven CRISPR/Cas12a Biosensing of UV-Induced DNA Lesions for Environmental Solar Exposure Surveillance.
Article in Environmental science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Monitoring environmentally relevant ultraviolet (UV) radiation is critical for understanding its biological impacts on ecosystems and human health. However, conventional UV dosimeters lack the molecular sensitivity to detect DNA-level damage that initiates such effects. Here, we present a CRISPR/Cas12a-based biosensing platform capable of quantifying solar UV exposure through the detection of UV-induced thymine dimers in DNA activators. This system harnesses mismatch-driven suppression of Cas12a activity, enabling a reduction in the fluorescence signal in response to UV-induced molecular lesions. The impact of thymine arrangement and the dimerization position of the activators on sensitivity were investigated. UV-induced diminution in Cas12a's
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