SynthesisImmunologic research2026
Effectiveness and safety of ravulizumab in anti-acetylcholine receptor antibody-positive (AChR-Ab+) generalized myasthenia gravis: a systematic review and meta-analysis.
Synthesis in Immunologic research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
objectiveTo evaluate the effectiveness and safety of ravulizumab in patients with anti-acetylcholine receptor antibody-positive generalized myasthenia gravis (AChR-Ab+ gMG).
methodsA systematic search was conducted in PubMed, Scopus, Web of Science, and Cochrane CENTRAL up to May 3, 2025. Eligible studies included clinical trials and observational studies assessing ravulizumab in MG. Two independent reviewers performed study selection and data extraction. Outcomes included the Quantitative Myasthenia Gravis (QMG) score, Myasthenia Gravis Activities of Daily Living (MG-ADL) score, Myasthenia Gravis Quality of Life 15-item revised scale (MG-QoL15r), corticosteroid dose, clinically meaningful improvement (≥ 2-point reduction in MG-ADL score), and adverse events (AEs). We used random-effects models to calculate pooled mean differences (MD) and proportions with 95% confidence intervals (CIs), and heterogeneity was assessed via I2 statistics.
resultsSix studies involving 321 patients (mean age: 56.27 ± 18.78 years) were included. Ravulizumab significantly improved QMG (MD: -2.91 points, 95% CI: [-4.50 to -1.32]), MG-ADL (MD: -2.64 points, 95% CI: [-3.75 to -1.54]), and MG-QoL15r (MD: -4.61 points, 95% CI: [-8.44 to -0.77]) scores. Clinically meaningful improvement was observed in 69% of patients (95% CI: [42% to 96%]). The corticosteroid dose was reduced by 5.98 mg/day (95% CI: [-7.71 to -4.25]). AEs were reported in 80.52% of patients; 28.5% experienced serious AEs.
conclusionsRavulizumab significantly improved QMG and MG-ADL scores and quality of life in AChR-Ab+ gMG patients, with a minimal steroid-sparing effect. Given the generally favorable safety profile, these findings support ravulizumab as a treatment option for patients with AChR-Ab+ gMG.
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