ReviewAlcohol and alcoholism (Oxford, Oxfordshire)2026
Alcohol-medication interactions among older people: a narrative review on age-specific evidence.
Review in Alcohol and alcoholism (Oxford, Oxfordshire), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAlcohol use is relatively common in older adults, representing a challenge for geriatricians. Older people are also prone to chronically taking multiple medications. Concerns are raised about potential alcohol-medication interactions (AMIs). This review aims to summarize current evidence on AMIs in older adults.
methodsWe conducted a literature search using MEDLINE up to 18 June 2025. Of 481 identified studies, 37 were considered pertinent and discussed in this review.
resultsEpidemiological data reveal that slightly over 25% (from ~20% to 80%) of older adults concurrently take alcohol and potentially interact with medications. Negative effects related to potential AMIs range from excessive sedation when old people take benzodiazepines, opioids, or antipsychotics, to hypoglycemia when they take sulfonylureas. Pharmacokinetic modifications can depend on physiological age-related changes in the human body. This evidence mostly derives from studies not focused on older adults.
conclusionsDespite their clinical importance, few studies focus on AMIs in older adults. The limited awareness among both healthcare providers and patients represents a significant public health issue. Routine alcohol use screening, universally shared lists of potential AMIs, and larger longitudinal studies are necessary to further explore the theme and mitigate risks.
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