ReviewInternational dental journal2026
Advancements in Bimetallic Metal-Organic Frameworks for Oral Medicine.
Review in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Design, synthesis, and biomedical evaluation of Ag/Cu bimetallic MOFs for controlled drug delivery and synergistic therapeutic applications.RSC advances · 2026Article
- Polysaccharide based biomaterials for advanced wound healing applications.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The characteristic oral environment - with its dynamic clearance, moisture, microbial load, and inflammatory potential - makes oral diseases highly prevalent and therapeutically challenging. Metal-organic frameworks (MOFs), an emerging class of inorganic-organic hybrid porous coordination materials, have become pivotal in modern biomedical engineering due to their facile synthesis, high surface area, large loading capacity, exceptional ion storage capability, tunable composition and pore size, and pH-responsive behaviour. To further enhance their performance, bimetallic metal-organic frameworks (BMOFs) have been constructed by incorporating two metal ions with functionalized organic ligands. Leveraging synergistic multimetallic effects and structural tunability, BMOFs exhibit significant potential in biomedical applications, including antibacterial activity, catalysis, and drug delivery. Exploratory applications of BMOFs in the prevention and treatment of oral diseases have already emerged, spanning periodontitis management, caries prevention, oral tissue regeneration, and targeted cancer therapy. Nevertheless, challenges remain in terms of biosafety, long-term stability, in vivo degradation behaviour, and scalable fabrication. This review summarizes the synthesis strategies and functionalization approaches of BMOFs, the selection of metal pairs, and their synergistic mechanisms, with a focus on their applications in oral biofilm infections, inflammatory diseases, oromaxillofacial bone tissue engineering scaffolds, and cancer therapy. Additionally, it discusses current challenges related to biocompatibility, technical limitations, and the clinical translation of these technologies. By correlating the fundamental design principles of BMOFs with the diagnostic and therapeutic demands of oral diseases, this review aims to facilitate translational research and promote the development of BMOFs as innovative and efficient strategies for addressing a range of oral pathologies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.