Evidence map›Paper›PMID 41936713›Full record

ArticleGeroScience2026

Gait speed and domain-specific cognitive performance in a diverse cohort of the oldest-old: the LifeAfter90 Study.

Rifat B Alam, Hilary L Colbeth, Alexander Ivan B Posis, Maria M Corrada, Kristen M George, Paola Gilsanz, Cathy Liu, Katherine Colcord, Nancy X Chen, Rachel A Whitmer

Abstract read
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In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rifat B AlamUniversity of California, Davis, CA, USA. rbalam@health.ucdavis.edu.ORCID http://orcid.org/0000-0002-4896-3063
Hilary L ColbethUniversity of California, Davis, CA, USA.
Alexander Ivan B PosisUniversity of California, Davis, CA, USA.
Maria M CorradaUniversity of California, Irvine, CA, USA.
Kristen M GeorgeUniversity of California, Davis, CA, USA.
Paola GilsanzKaiser Permanente, Pleasanton, CA, USA.
Cathy LiuUniversity of California, Davis, CA, USA.
Katherine ColcordUniversity of California, Irvine, CA, USA.
Nancy X ChenUniversity of California, Davis, CA, USA.
Rachel A WhitmerUniversity of California, Davis, CA, USA.

Funding

Epidemiology of Age-related Dementia, Mild Cognitive Impairment and Brain Pathology in Cohort of Oldest-OldR01AG056519 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Maria Corrada, Paola Gilsanz · 2022 to 2026
$25.8M
NIA NIH HHS R01 AG056519NIA NIH HHS R01AG056519
6 · The paper itself

Abstract

Gait speed is a robust marker of health in older adults and is associated with cognition, yet few studies have examined this in the oldest-old and if there are differences by cognitive domain. We examined the association between gait speed and cognition across three domains in individuals aged 90 + , considering differences by gender and device use. Then, 502 participants were included from the LifeAfter90 Study. Baseline gait speed (meters/second) was measured using the 4-meter walk test. The Spanish and English Neuropsychological Assessment Scale assessed executive function (EF), verbal episodic memory (VEM), and semantic memory (SM). We tested cross-sectional and longitudinal associations of gait speed with cognition using linear mixed-effects models adjusted for age, gender, race/ethnicity, education, device, interview mode, and practice effects. Models were stratified by gender and device. Participants' mean age was 92.9 ± 2.4 years, 62.6% female, 22.3% African American/Black, 20.9% Asian, 12.3% Hispanic/Latino, 35.9% White, and 8.6% multiracial/other. Faster gait speed was associated with better EF (β(95%CI) = 1.3 (0.9, 1.8)), VEM (0.7 (0.1, 1.2)), and SM (0.8 (0.4, 1.3)). Gender-stratified models showed better EF and SM in both sexes and better VEM in women. Device-stratified models showed better EF and SM in both groups and better VEM in nondevice users. Longitudinally, faster gait speed was associated with slower SM decline (0.1 (0.0003, 0.2)). No other longitudinal associations were significant in pooled or stratified analyses. Faster baseline gait speed was linked to better cognitive performance and slower SM decline. Findings varied by domain, gender, and device use, highlighting gait speed's utility in reflecting cognitive variability among those with exceptional longevity.

Indexed as

CognitionCognitive domainsGait speedLongitudinal studyMobilityOldest-old

Identifiers

PMID41936713

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.