Evidence map›Paper›PMID 41937256›Full record

ArticleAnnals of clinical and translational neurology2026

Choroid Plexus Enlargement and USPIO-Based Inflammatory Feature in Cerebral Small Vessel Disease.

Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu and 2 more

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In one paragraph

Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Yongqiang QuDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Xiaoning RenDepartment of Anesthesiology, Fujian Medical University Union Hospital, Fuzhou, China.
Cuihua FanDepartment of Blood Transfusion, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Chun LiDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Lijie ZhangDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Zaiqiang ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-0053-3451
Shaowu LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zhongmeng LaiDepartment of Anesthesiology, Fujian Medical University Union Hospital, Fuzhou, China.
Bin CaiDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.ORCID https://orcid.org/0000-0003-2659-9376
Ying FuDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.ORCID https://orcid.org/0000-0002-1590-3945
Yi LinDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Zhibao ZhuDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.ORCID https://orcid.org/0009-0003-3964-6618

Funding

Joint Funds for the Innovation of Science and Technology of Fujian Province 2021Y9131Major Scientific Research Program for Young and Middle-aged Health Professionals of Fujian Province 2022ZQNZD005National Natural Science Foundation of China 82371349National Natural Science Foundation of China U21A20360National Natural Science Foundation of China U22A20296
6 · The paper itself

Abstract

objectiveThe choroid plexus (CP) is a key component of the blood-cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of inflammation using ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced MRI.

methodsIn this study, 111 CSVD patients and 69 healthy controls (HC) underwent 3.0 T conventional MRI to quantify CPV in the lateral (LV), third (3 V), and fourth (4 V) ventricles. CSVD burden was evaluated using visual assessment scales, including indicators such as white matter hyperintensities (WMH), lacunes, basal ganglia-enlarged perivascular spaces (BG-EPVS), cerebral microbleeds (CMBs), and brain atrophy (BA). A subgroup (22 CSVD, 10 HC) underwent USPIO-enhanced MRI to measure the change of signal intensity ratio (∆SIR) as a feature of inflammatory activity in the CP and deep gray matter nuclei.

resultsCSVD patients showed significantly larger CPV (all p < 0.001). CPV demonstrated significant positive correlations with the severity of conventional CSVD imaging markers (all p < 0.05). USPIO-enhanced MRI revealed an increased ΔSIR in the LV, 3 V, and 4 V CP (all p < 0.05). Furthermore, increased USPIO uptake was observed in deep gray matter nuclei in CSVD. Crucially, a positive correlation was found between LV CP volume and ΔSIR (r = 0.375, p = 0.034), and the LV CP inflammation was strongly correlated with the hippocampus (r = 0.582, p < 0.001).

interpretationCP enlargement is prominent in CSVD and closely linked to the CSVD imaging burden. CP inflammation is associated with increased volume. CP may be a novel biomarker to help diagnose, monitor, and treat neuroinflammation in CSVD.

Indexed as

choroid plexusCSVDinflammationMRIUSPIO

Identifiers

PMID41937256
PMCPMC13394647

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.