Evidence map›Paper›PMID 41937268›Full record

ArticleJournal of neuroscience research2026

The Transcription Factors Six3 and Six6 in Neuromedin-S Neurons Differentially Affect Circadian Rhythms.

Brooke M Van Loh, Geneva A Dunn, Lauren E Chun, Meera M Patel, Nay Chi P Naing, Duong Nguyen, Alexandra M Yaw, Michael R Gorman, Jessica Cassin, Pamela L Mellon and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Brooke M Van LohDepartment of Animal Science, Michigan State University, East Lansing, Michigan, USA.
Geneva A DunnDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Science and Medicine, University of California San Diego, La Jolla, California, USA.ORCID https://orcid.org/0009-0002-3147-1596
Lauren E ChunDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Science and Medicine, University of California San Diego, La Jolla, California, USA.
Meera M PatelDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Science and Medicine, University of California San Diego, La Jolla, California, USA.
Nay Chi P NaingDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Science and Medicine, University of California San Diego, La Jolla, California, USA.
Duong NguyenDepartment of Animal Science, Michigan State University, East Lansing, Michigan, USA.
Alexandra M YawDepartment of Animal Science, Michigan State University, East Lansing, Michigan, USA.
Michael R GormanDepartment of Psychology, University of California San Diego, La Jolla, California, USA.
Jessica CassinDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Science and Medicine, University of California San Diego, La Jolla, California, USA.ORCID https://orcid.org/0000-0003-0279-2294
Pamela L MellonDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Science and Medicine, University of California San Diego, La Jolla, California, USA.
Hanne M HoffmannDepartment of Animal Science, Michigan State University, East Lansing, Michigan, USA.
Karen J TonsfeldtDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Science and Medicine, University of California San Diego, La Jolla, California, USA.ORCID https://orcid.org/0000-0001-8044-8857

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
The Role of FSH in Female InfertilityP50HD012303 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, R JEFFREY · 1985 to 2020
$7.5M
TRAINING IN REPRODUCTIVE SCIENCEST32HD007203 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAMELA L MELLON · 1988 to 2026
$4.8M
NEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUSR01DK044838 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MELLON, PAMELA L · 1991 to 2011
$3.8M
Neurosecretory Gene Expression in the HypothalamusR01HD100580 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MELLON, PAMELA L · 2020 to 2024
$2.7M
Reproductive and Developmental Sciences Training Program - T32T32HD087166 · NICHD · MICHIGAN STATE UNIVERSITY · PI Ronald L Chandler, Keith E Latham · 2016 to 2026
$2.5M
Chemical exposure disruption of the placental circadian clockR01ES035691 · NIEHS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Almudena Veiga-Lopez · 2024 to 2026
$2.2M
Neurosecretory Gene Expression in the HypothalamusR01HD072754 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MELLON, PAMELA L · 2012 to 2016
$1.7M
NCI NIH HHS P30 CA023100NICHD NIH HHS F32 HD098805NICHD NIH HHS K99 HD084759NICHD NIH HHS K99 HD107217NICHD NIH HHS P50 HD012303NICHD NIH HHS R01 HD072754NICHD NIH HHS R01 HD082567NICHD NIH HHS R01 HD100580NICHD NIH HHS T32 HD007203NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK044838NIEHS NIH HHS P42 ES010337NIEHS NIH HHS R01 ES035691NIGMS NIH HHS K12 GM068524NIH HHS F31 HD114529NIH HHS F32 HD090837NIH HHS F32 HD098805NIH HHS F32 HD107852NIH HHS K12 GM068524NIH HHS K99 HD107217NIH HHS K99 HD113843NIH HHS K99 NS119291NIH HHS P30 CA023100NIH HHS P30 DK063491NIH HHS P30 NS047101NIH HHS P42 ES010337NIH HHS P50 HD012303NIH HHS R00 HD084759NIH HHS R01 HD072754NIH HHS R01 HD082567NIH HHS R01 HD100580NIH HHS T32 HD007203NIH HHS T32 HD087166NINDS NIH HHS K99 NS119291NINDS NIH HHS R00 NS119291U.S. Department of Agriculture MICL1018024
6 · The paper itself

Abstract

Circadian rhythms are ~24-h rhythms generated by the suprachiasmatic nucleus (SCN) in the mammalian hypothalamus. The regulation of circadian rhythms and downstream processes is highly dependent on the proper development and function of the SCN. Six3 and Six6 are homologous homeodomain transcription factors that have been shown to be required for SCN development; intriguingly, both Six3 and Six6 remain expressed in the adult SCN. To determine the role of Six3 and Six6 in the SCN after neurogenesis, we used Cre-lox to conditionally knockdown either Six3 or Six6 from cells that express neuromedin-S (NMS), a neuropeptide expressed in approximately half of SCN neurons. We found that the Nms

Indexed as

Circadian RhythmHomeodomain ProteinsNerve Tissue ProteinsNeuronsNeuropeptidesSuprachiasmatic NucleusAnimalsFemaleHomeobox Protein SIX3MaleMiceMice, TransgenicNeurogenesisTrans-ActivatorsHomeobox Protein SIX3Homeodomain ProteinsNerve Tissue Proteinsneuromedin SNeuropeptidesSix6 protein, mouseTrans-Activatorscircadian rhythmsneuromedin‐sreproductionSix3Six6suprachiasmatic nucleus

Identifiers

PMID41937268
PMCPMC13051014

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.