Evidence map›Paper›PMID 41937269›Full record

ArticleJournal of neurotrauma2026

Cerebral Autoregulation in Severe Traumatic Brain Injury: Source of Index, Timing, and Relationship to Spreading Depolarization.

Alexandria Marino, Abhinav Kareddy, Xin-Qun Wang, Chaitali Harge, Thomas R Jones, C William Shuttleworth, Andrew P Carlson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexandria MarinoDepartment of Neurosurgery, Marshall University Joan C Edwards School of Medicine, Huntington, Virginia, USA.ORCID 0000-0003-3827-3357
Abhinav KareddyUniversity of Virginia School of Medicine, Huntington, West Virginia, USA.
Xin-Qun WangDepartment of Public Health Sciences, University of Virginia, Huntington, West Virginia, USA.
Chaitali HargeDepartment of Neurosurgery, University of Virginia, Charlottesville, Virginia, USA.
Thomas R JonesDepartment of Psychiatry, University of New Mexico, Albuquerque, New Mexico, USA.
C William ShuttleworthDepartment of Neurosciences, University of New Mexico, Albuquerque, New Mexico, USA.
Andrew P CarlsonDepartment of Neurosurgery, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0003-2189-3699

Funding

Clinical Stimulation and Spreading DepolarizationR01NS128006 · NINDS · UNIVERSITY OF VIRGINIA · PI Andrew Phillip Carlson · 2023 to 2026
$1.6M
NINDS NIH HHS R01 NS128006
6 · The paper itself

Abstract

Impaired cerebral autoregulation is a contributor to secondary injury in traumatic brain injury (TBI) and is associated with worse outcomes. The mechanism of injury progression from impaired autoregulation is suggested to be related to triggering of spreading depolarization (SDs) events-massive waves of cellular dysfunction implicated in secondary injury. The most-studied continuous measurement of autoregulation is the pressure reactivity index (PRx), a rolling correlation between waveform level mean arterial pressure (MAP) and intracranial pressure. However, alternative indices using correlation of MAP with brain tissue oxygen tension (PbtO

Indexed as

cerebral autoregulationcerebral blood flowcerebral perfusion pressuresecondary brain injuryspreading depolarization

Identifiers

PMID41937269
PMCPMC13343230

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.