Evidence map›Paper›PMID 41937611›Full record

ArticleCardiovascular therapeutics2026

The Association Between Sedentary Behavior and Cardiovascular Disease Risk: An Analysis Based on NHANES Data.

Heming Huang, Zhe Zhao, Zemou Yu, Fan Feng, Zaifeng Zhang, Bingge Fan, Ling-Bing Meng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Heming HuangGeriatric Department, Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China, jnu.edu.cn.
Zhe ZhaoDepartment of Pharmacy, Peking University Third Hospital, Beijing, China, puh3.net.cn.ORCID https://orcid.org/0009-0000-8562-4311
Zemou YuDepartment of Neurology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China, bch.com.cn.ORCID https://orcid.org/0000-0002-9658-4869
Fan FengDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China, cacms.ac.cn.ORCID https://orcid.org/0009-0003-7674-1323
Zaifeng ZhangCenter of Laboratory Medicine, State Key Laboratory of Cardiovascular Disease, Beijing Key Laboratory for Molecular Diagnostics of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College/National Center for Cardiovascular Diseases, Beijing, China, fuwaihospital.org.ORCID https://orcid.org/0000-0001-5529-4614
Bingge FanDepartment of Endocrinology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China, hebmu.edu.cn.ORCID https://orcid.org/0009-0009-7935-8606
Ling-Bing MengCardiometabolic Medicine Center, National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, cacms.ac.cn.ORCID https://orcid.org/0009-0008-5823-130X

Funding

National Natural Science Foundation of China 82400543
6 · The paper itself

Abstract

backgroundSedentary behavior has become a major global public health challenge and is closely associated with cardiovascular disease (CVD). Sedentary behavior not only increases the risk of various chronic diseases but also poses significant threats to cardiovascular health. Existing studies suggest that sedentary behavior is an independent risk factor for CVD, but the underlying mechanisms across different populations remain inadequately explored.

methodsThis study analyzed data from 31,034 participants in the National Health and Nutrition Examination Survey (NHANES) to investigate the relationship between sedentary behavior and CVD. Standardized questionnaires were used to collect sociodemographic and health information. Statistical analyses, including weighted t-tests, forest plots, logistic regression, and restricted cubic spline regression, were employed to examine the effects of sedentary time on CVD and related influencing factors.

resultsThe findings indicated that prolonged sedentary time was significantly associated with an increased risk of CVD, particularly among individuals aged 60 and older (OR = 17.297, p < 0.001) Factors such as age, gender, and hyperlipidemia played a critical role in the relationship between sedentary behavior and CVD. Restricted cubic spline regression analysis revealed that CVD risk increased markedly after 250 min of sedentary time, with a pronounced rise after 750 min. Multivariate regression analysis also confirmed the negative impact of sedentary behavior on cardiovascular health.

conclusionSedentary behavior is a significant independent risk factor for CVD, and reducing sedentary time is associated with a lower CVD risk. Enhancing public awareness of the hazards of sedentary behavior and implementing effective interventions, especially for the elderly, may contribute to improved cardiovascular health.

Indexed as

Cardiovascular DiseasesSedentary BehaviorAdultAgedAge FactorsCross-Sectional StudiesFemaleHeart Disease Risk FactorsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisNutrition SurveysOdds RatioProtective Factorscardiovascular diseaseCVDNHANESrisk factorssedentary behavior

Identifiers

PMID41937611
PMCPMC13051795

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.