Evidence map›Paper›PMID 41937900›Full record

ReviewFrontiers in pediatrics2026

Risks and benefits of face masks in children.

Kai Kisielinski, Claudia Steigleder-Schweiger, Susanne Wagner, Stephan Korupp, Stefan Hockertz, Oliver Hirsch

Abstract readReview
In one paragraph

Review in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kai KisielinskiClinical Medicine (Surgery), Emergency Medicine and Social Medicine, Private Practice, Düsseldorf, Germany.
Claudia Steigleder-SchweigerDepartment of Paediatrics, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria.
Susanne WagnerNon Clinical Expert, Veterinarian, Wagner MSL Management, Mahlow, Germany.
Stephan KoruppEmergency Medicine, Private Practice, Aachen, Germany.
Stefan HockertzToxicology, Pharmacology, Immunology, TPI consult AG, Baar, Switzerland.
Oliver HirschFOM University of Applied Sciences, Siegen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Children, a significant and vulnerable portion of the global population, are particularly susceptible to environmental factors. Methods: We conducted a systematic search and scoping review of 3,144 articles, including 107 publications from medical literature, to assess mask use in children during the 2020-2023 pandemic. We examined expected viral protection vs. scientific evidence and side effects, synthesizing findings with SWiM and GRADE frameworks for evidence certainty and the Cochrane adverse effects approach. Results: Masking children lacks ecological validity, with high-quality studies showing little real-world effectiveness against viruses. On the other hand, side effects can clearly be identified. Masks contain hazardous materials (carcinogens, heavy metals, organic compounds, and microplastic), impacting childreńs health by altering inhaled air (including elevated carbon dioxide) and causing many physical symptoms and bio-psychosocial issues (MIES, mask-induced exhaustion syndrome), akin to sick building syndrome. Toxicological assessments highlight risks to biology of the young. Evidence certainty is high for non-effectiveness, moderate for risks and side effects, and low to very low for viral protection or benefits in children. Conclusions: With a negligible COVID-19 mortality rate in children (0.0003%) and no evidence of child-to-child or school-based transmission, masks offered little benefit during the pandemic. The documented adverse effects-respiratory impairment, toxicity, and health risks-outweigh any justification for their mandatory use. An individual risk-benefit analysis is essential (individual medical advice), but this review suggests avoiding this intervention in children because of its numerous downsides and the lack of proven efficacy. It is the responsibility of political leaders to address our findings.

Indexed as

adverse effectschildrenhealth risk assessmentlong-term adverse effectsmasksMIESN95risk

Identifiers

PMID41937900
PMCPMC13047964

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.