ArticleInternational journal of women's health2026
Integrative Mendelian Randomization and Whole-Blood Transcriptomic Analysis Implicate a Myeloid-Inflammation Axis in Polycystic Ovary Syndrome.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Immune dysregulation and low-grade inflammation are central to the pathophysiology of polycystic ovary syndrome (PCOS). However, putative causal relationships inferred from genetic instruments and their consistency with transcriptomic readouts remain underexplored. Methods: We conducted two-sample Mendelian randomization (MR) to estimate potential causal relationships between 731 immune immunophenotypes and PCOS. In an independent, small whole-blood transcriptomic dataset (Gene Expression Omnibus [GEO]: GSE54248; PCOS n=4, controls n=4), we applied gene-signature-based deconvolution (xCell and Microenvironment Cell Populations-counter [MCP-counter]) and single-sample pathway scoring to profile myeloid cell composition and IL-6/JAK/STAT3 and tumor necrosis factor-α/nuclear factor κB (TNF-α/NF-κB) pathway activity. Robustness of the MR findings was examined by standard sensitivity analyses. Results: MR indicated opposite-direction associations for key myeloid traits: higher absolute monocyte count was inversely associated with PCOS risk (odds ratio [OR] per standard deviation [SD] increase 0.52, 95% confidence interval [CI] 0.39-0.69, Conclusion: Genetic and transcriptomic evidence jointly support the concept of a myeloid-inflammation axis in PCOS. The inverse MR association for absolute monocyte count alongside positive risk for CD33
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.