ArticleAACE endocrinology and diabetes
Changes in Bone Mineral Density Following Levothyroxine Therapy in Hypothyroidism - A Prospective, Observational Study.
Article in AACE endocrinology and diabetes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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9 authors.
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Abstract
Background/Objective: Thyroid hormones play a significant role in skeletal metabolism and bone turnover. We investigated the effect of levothyroxine (LT4) replacement on bone mineral density (BMD) using dual-energy x-ray absorptiometry in newly diagnosed patients with hypothyroidism. Methods: In this prospective, observational study, we included 70 adult patients newly diagnosed with either overt hypothyroidism (OH) or subclinical hypothyroidism (SCH). LT4 was initiated at 1.6 μg/kg/d and 25 μg/d in OH and SCH, respectively, and the dose was adjusted every 2 months to achieve euthyroidism. BMD was done at baseline and 2 months after attaining euthyroidism. The results were analysed using appropriate statistical methods, and a Results: The study participants (51F; 19M) had a mean age of 36.6 ± 10.7 years, body weight of 63.5 ± 13.6 kg, and a body mass index of 25.5 ± 4.2 kg/m Conclusion: LT4 therapy correlated with change of BMD at the lumbar spine and femoral neck within 1 year. Further studies involving a bigger sample, long-duration follow-up, along with histomorphometric and fracture data, are required to confirm the findings of our study.
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