ArticleCommunications physics2026
De-aberration for noninvasive transcranial photoacoustic computed tomography through an adult human skull.
Article in Communications physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Stochastic numerical head phantoms to enable virtual imaging studies of transcranial photoacoustic computed tomography.Photoacoustics · 2026Article
- Multiscale photoacoustic imaging of stroke in preclinical models and future directions toward clinical translation [Invited].Biomedical optics express · 2026Review
- Clinical translation of photoacoustic imaging using exogenous molecular contrast agents [Invited].Biomedical optics express · 2025Review
- Fast aberration correction in 3D transcranial photoacoustic computed tomography via a learning-based image reconstruction method.Photoacoustics · 2025Article
- Transcranial Photoacoustic Tomography De-Aberrated Using Boundary Elements.IEEE transactions on medical imaging · 2025Article
- Ultrasound-assisted aberration correction of transcranial photoacoustic imaging based on angular spectrum theory.Photoacoustics · 2024Article
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11 authors.
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Abstract
Noninvasive transcranial photoacoustic computed tomography (PACT) of the human brain, despite its clinical potential as a complementary technology to functional MRI, remains impeded by the acoustic distortion induced by the human skull. The distortion, which is attributed to the markedly different material properties of the skull relative to soft tissue, results in heavily aberrated PACT images. Herein, we report an experimental demonstration of the de-aberration of PACT images through an ex-vivo adult human skull using a homogeneous elastic model for the skull. Using only the geometry, position, and orientation of the skull, obtained from adjunct imaging data and fiducial markers, we faithfully de-aberrate the PACT images of light-absorbing phantoms acquired through an ex-vivo human skull for different levels of phantom complexity and positions. We also demonstrate the generality of our results by attaining a similar extent of de-aberration through a second ex-vivo human skull. Our work addresses the longstanding challenge of skull-induced aberrations in transcranial PACT and advances the field towards unlocking the full potential of transcranial human brain PACT.
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