ArticleJournal of oral microbiology2026
Interplay between genetically predicted gut microbiota and chronic apical periodontitis: a Mendelian randomization analysis.
Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Whether alterations in the gut microbiota play a causal role in chronic apical periodontitis (CAP) remains uncertain. A two-sample Mendelian randomization (MR) analysis was used in this study to assess the potential causal effect of gut microbiota on CAP risk. Methods: Gut microbiota summary statistics were from the MiBioGen consortium's largest GWAS, and CAP data from the FinnGen project. The inverse variance-weighted method was the main analytic approach, and sensitivity analyses verified instrument robustness. Results: Two microbial taxa showed positive causal effect with CAP: Conclusions: This MR analysis provides evidence of a genetic relationship between gut microbiota composition and susceptibility to CAP. The findings broaden our understanding of microbial changes in CAP-affected tissues, and suggest a genetic association between alterations in the composition of the gut microbiota and CAP risk.
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