Evidence map›Paper›PMID 41938708›Full record

ReviewGenes & diseases2026

The role and potential therapeutic intervention of cellular senescence in intervertebral disc degeneration.

Yunbo Guan, Xuedong Bai, Chao Li, Ziqiang Zhang, Qing He, Lin Chen, Yangli Xie, Zuqiang Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes & diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yunbo GuanDepartment of Orthopedics, The Sixth Medical Center, General Hospital of Chinese PLA, Beijing 100048, China.
Xuedong BaiDepartment of Orthopedics, The Sixth Medical Center, General Hospital of Chinese PLA, Beijing 100048, China.
Chao LiDepartment of Orthopedics, The Sixth Medical Center, General Hospital of Chinese PLA, Beijing 100048, China.
Ziqiang ZhangDepartment of Orthopedics, The Sixth Medical Center, General Hospital of Chinese PLA, Beijing 100048, China.
Qing HeDepartment of Orthopedics, The Sixth Medical Center, General Hospital of Chinese PLA, Beijing 100048, China.
Lin ChenDepartment of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma and Chemical Poisoning, Army Medical Center, Daping Hospital, Army Medical University, Chongqing 400038, China.
Yangli XieDepartment of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma and Chemical Poisoning, Army Medical Center, Daping Hospital, Army Medical University, Chongqing 400038, China.
Zuqiang WangDepartment of Orthopedics, The Sixth Medical Center, General Hospital of Chinese PLA, Beijing 100048, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intervertebral disc degeneration (IDD) is a common cause of low back pain that causes significant debilitation. The intricate mechanisms governing intervertebral disc homeostasis are substantially impacted by cellular senescence, which plays crucial roles in both pathological and physiological contexts. In this review, we provide a comprehensive overview of cellular senescence in the pathogenesis of IDD. Specifically, we summarize the merits and limitations of the methodologies utilized in prior investigations to determine cellular senescence and the potential regulatory mechanisms underlying it in the progression of IDD. Furthermore, we describe therapeutic strategies that aim to inhibit cellular senescence, which may alleviate the pathogenesis of IDD. At last, we discuss the challenges and prospects of translational research on targeting cellular senescence in IDD treatment.

Indexed as

AutophagyCellular senescenceIntervertebraldisc degenerationSenescence-associated secretory phenotypeSenotherapeutics

Identifiers

PMID41938708
PMCPMC13050087

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.