Evidence map›Paper›PMID 41938796›Full record

ArticleJournal of asthma and allergy2026

Eosinophil-Derived Neurotoxin: A Potential Biomarker for Allergic Bronchopulmonary Aspergillosis.

Minfang Zou, Yun Pan, Yan Yang, Xiaofei Liu, Rong Zeng, Liang Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of asthma and allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Minfang ZouDepartment of General Practice, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China.
Yun PanDepartment of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Featured Laboratory of Respiratory Immunology and Regenerative Medicine in Universities of Shandong, Jinan Clinical Research Center for Respiratory Disease, Jinan, Shandong, People's Republic of China.
Yan YangDepartment of NHC Key Laboratory of Otorhinolaryngology, Shandong University, Jinan, Shandong, People's Republic of China.
Xiaofei LiuDepartment of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Featured Laboratory of Respiratory Immunology and Regenerative Medicine in Universities of Shandong, Jinan Clinical Research Center for Respiratory Disease, Jinan, Shandong, People's Republic of China.
Rong ZengDepartment of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Featured Laboratory of Respiratory Immunology and Regenerative Medicine in Universities of Shandong, Jinan Clinical Research Center for Respiratory Disease, Jinan, Shandong, People's Republic of China.
Liang DongDepartment of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, People's Republic of China.ORCID 0000-0001-7707-9982

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Eosinophil-derived neurotoxin (EDN) has emerged as a potential biomarker in asthma. Allergic bronchopulmonary aspergillosis (ABPA) is a severe complication of asthma. This study aimed to investigate serum EDN levels in ABPA and assess the diagnostic utility of serum EDN in distinguishing ABPA from Methods: This is a single-center retrospective analysis of data from patients initially diagnosed with ABPA and asthma between 2021 and 2023. Eighteen patients with ABPA, 11 with unsensitized asthma (UA), 10 with ASA, and 18 healthy controls were enrolled. Serum EDN levels were measured by enzyme-linked immunosorbent assay (ELISA). Comparisons among groups were performed using Mann-Whitney Results: Serum EDN levels were significantly higher in ABPA patients (median 132.8 ng/mL, IQR: 106.1-256.4) compared to healthy controls (39.7 ng/mL, IQR: 26.6-53.5), UA (59.4 ng/mL, IQR: 48.9-70.1), and ASA (67.6 ng/mL, IQR: 33.3-104.0) after Bonferroni correction (all Conclusion: EDN levels are significantly elevated in ABPA and correlates with key disease markers, including eosinophil counts,

Indexed as

ABPAallergic bronchopulmonary aspergillosisAspergillus fumigatus–sensitized asthmaasthmabiomarkereosinophil-derived neurotoxin

Identifiers

PMID41938796
PMCPMC13050161

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.